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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1
Author(s): Philp, Andrew
Hamilton, David Lee
Baar, Keith
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Keywords: mammalian target of rapamycin complex 1
Isometric exercise
Muscle strength
Issue Date: Feb-2011
Date Deposited: 29-Apr-2013
Citation: Philp A, Hamilton DL & Baar K (2011) Signals mediating skeletal muscle remodeling by resistance exercise: PI3-kinase independent activation of mTORC1. Journal of Applied Physiology, 110 (2), pp. 561-568.
Abstract: For over 10 years, we have known that the activation of the mammalian target of rapamycin complex 1 (mTORC1) has correlated with the increase in skeletal muscle size and strength that occurs following resistance exercise. Initial cell culture and rodent models of muscle growth demonstrated that the activation of mTORC1 is common to hypertrophy induced by growth factors and increased loading. The further observation that high loads increased the local production of growth factors led to the paradigm that resistance exercise stimulates the autocrine production of factors that act on membrane receptors to activate mTORC1, and this results in skeletal muscle hypertrophy. Over the last few years, there has been a paradigm shift. From both human and rodent studies, it has become clear that the phenotypic and molecular responses to resistance exercise occur in a growth factor-independent manner. Although the mechanism of load-induced mTORC1 activation remains to be determined, it is clear that it does not require classical growth factor signaling.
DOI Link: 10.1152/japplphysiol.00941.2010
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