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dc.contributor.authorTimmons, James Aen_UK
dc.contributor.authorWennmalm, Kristianen_UK
dc.contributor.authorLarsson, Olaen_UK
dc.contributor.authorWalden, Tomas Ben_UK
dc.contributor.authorLassmann, Timoen_UK
dc.contributor.authorPetrovic, Natasaen_UK
dc.contributor.authorHamilton, David Leeen_UK
dc.contributor.authorGimeno, Ruth Een_UK
dc.contributor.authorWahlestedt, Claesen_UK
dc.contributor.authorBaar, Keithen_UK
dc.contributor.authorNedergaard, Janen_UK
dc.contributor.authorCannon, Barbaraen_UK
dc.description.abstractAttainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant mitochondria and increased energy expenditure potential, is a legitimate strategy for combating obesity. The unique transcriptional regulators of the primary brown adipocyte phenotype are unknown, limiting our ability to promote brown adipogenesis over white. In the present work, we used microarray analysis strategies to study primary preadipocytes, and we made the striking discovery that brown preadipocytes demonstrate a myogenic transcriptional signature, whereas both brown and white primary preadipocytes demonstrate signatures distinct from those found in immortalized adipogenic models. We found a plausible SIRT1-related transcriptional signature during brown adipocyte differentiation that may contribute to silencing the myogenic signature. In contrast to brown preadipocytes or skeletal muscle cells, white preadipocytes express Tcf21, a transcription factor that has been shown to suppress myogenesis and nuclear receptor activity. In addition, we identified a number of developmental genes that are differentially expressed between brown and white preadipocytes and that have recently been implicated in human obesity. The interlinkage between the myocyte and the brown preadipocyte confirms the distinct origin for brown versus white adipose tissue and also represents a plausible explanation as to why brown adipocytes ultimately specialize in lipid catabolism rather than storage, much like oxidative skeletal muscle tissue.en_UK
dc.publisherNational Academy of Sciencesen_UK
dc.relationTimmons JA, Wennmalm K, Larsson O, Walden TB, Lassmann T, Petrovic N, Hamilton DL, Gimeno RE, Wahlestedt C, Baar K, Nedergaard J & Cannon B (2007) Myogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineages. Proceedings of the National Academy of Sciences, 104 (11), pp. 4401-4406.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectprincipal component analysisen_UK
dc.subjectIsometric exerciseen_UK
dc.subjectMuscle strengthen_UK
dc.titleMyogenic gene expression signature establishes that brown and white adipocytes originate from distinct cell lineagesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Hamilton_2007_Myogenic_gene_expression_signature.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleProceedings of the National Academy of Sciencesen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationStockholm Universityen_UK
dc.contributor.affiliationKarolinska Instituteten_UK
dc.contributor.affiliationKarolinska Instituteten_UK
dc.contributor.affiliationStockholm Universityen_UK
dc.contributor.affiliationKarolinska Instituteten_UK
dc.contributor.affiliationStockholm Universityen_UK
dc.contributor.affiliationMillennium Pharmaceuticals, Cambridgeen_UK
dc.contributor.affiliationKarolinska Instituteten_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationStockholm Universityen_UK
dc.contributor.affiliationStockholm Universityen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorTimmons, James A|en_UK
local.rioxx.authorWennmalm, Kristian|en_UK
local.rioxx.authorLarsson, Ola|en_UK
local.rioxx.authorWalden, Tomas B|en_UK
local.rioxx.authorLassmann, Timo|en_UK
local.rioxx.authorPetrovic, Natasa|en_UK
local.rioxx.authorHamilton, David Lee|0000-0002-5620-4788en_UK
local.rioxx.authorGimeno, Ruth E|en_UK
local.rioxx.authorWahlestedt, Claes|en_UK
local.rioxx.authorBaar, Keith|en_UK
local.rioxx.authorNedergaard, Jan|en_UK
local.rioxx.authorCannon, Barbara|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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