Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12224
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dc.contributor.authorMacaluso, Frank-
dc.contributor.authorBrooks, Naomi-
dc.contributor.authorvan, de Vyver Mark-
dc.contributor.authorVan, Tubbergh Karen-
dc.contributor.authorNiesler, Carola U-
dc.contributor.authorMyburgh, Kathryn H-
dc.date.accessioned2016-09-10T21:25:16Z-
dc.date.issued2012-08-
dc.identifier.urihttp://hdl.handle.net/1893/12224-
dc.description.abstractSatellite cells (SCs) are responsible for muscle repair following strenuous exercise or injury. SC responses to intervention have been studied, but most studies do not discuss or take into account the substantial variability in SC number among young individuals. We hypothesized that an active lifestyle reflected in higher VO 2max may be associated with greater SC number. As training alters basal p38-mitogen-activated protein kinase (MAPK) activity, which is associated with SC proliferation, SC count may also correlate with this stress signaling kinase. Muscle biopsies from vastus lateralis of eight male participants were analyzed for fiber type, myogenin, and p38/phospho-p38 MAPK using SDS-PAGE and Western blotting. Immunofluorescence was used to detect Pax7 + SCs. Two weeks following the biopsy, subjects underwent an incremental treadmill test to determine VO 2max. A strong positive correlation (P=0.0087) was found between the number of Pax7 + nuclei and VO 2max. Pax7 + cell number correlated negatively with phospho-p38/p38 MAPK (P=0.0006), but had no correlation with fiber type or myogenin. SC number is proportional to VO 2max, and hence it can be postulated that higher levels of physical activity activate SC proliferation but not fusion, underlining the relevance of exercise in stimulating SC pool size even without injury.en_UK
dc.language.isoen-
dc.publisherWiley-Blackwell / John Wiley and Sons-
dc.relationMacaluso F, Brooks N, van de Vyver M, Van Tubbergh K, Niesler CU & Myburgh KH (2012) Satellite cell count, VO2max, and p38 MAPK in inactive to moderately active young men, Scandinavian Journal of Medicine and Science in Sports, 22 (4), pp. e38-e44.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectPax7+en_UK
dc.subjectvastus lateralis muscleen_UK
dc.subjectphysical fitnessen_UK
dc.subjectmyogeninen_UK
dc.subjectfiber typeen_UK
dc.titleSatellite cell count, VO2max, and p38 MAPK in inactive to moderately active young menen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1111/j.1600-0838.2011.01389.x-
dc.identifier.pmid22092554-
dc.citation.jtitleScandinavian Journal of Medicine and Science in Sports-
dc.citation.issn0905-7188-
dc.citation.volume22-
dc.citation.issue4-
dc.citation.spagee38-
dc.citation.epagee44-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailn.e.brooks@stir.ac.uk-
dc.citation.date27/09/2011-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
dc.contributor.affiliationUniversity of KwaZulu-Natal-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000306687100006-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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