|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Alpha4 Beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysis|
Herrmann, Lucie L
Lonie, Jane A
Best, Jonathan J K
Ebmeier, Klaus P
Wyper, David J
nicotinic acetylcholine receptors
single photon emission tomography
|Citation:||Terriere E, Sharman M, Donaghey C, Herrmann LL, Lonie JA, Strachan M, Dougall N, Best JJK, Ebmeier KP, Pimlott S, Patterson J & Wyper DJ (2008) Alpha4 Beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: Methods of scan analysis, Neurochemical Research, 33 (4), pp. 643-651.|
|Abstract:||Five patients with Alzheimer's disease and five healthy volunteers were examined by SPECT with the nicotinic receptor ligand 123I-5-IA-85380. Patients were scanned before and after 6 weeks of treatment with donepezil. Quantification by regions of interest was reliable and the optimal normalisation procedure used cerebellar ratios. We found relative reductions in 5-IA binding capacity in patients in thalamus, frontal and central regions of interest of approximately one standard deviation unit (Cohen's d = 1). Reductions in binding after treatment with the acetylcholinesterase inhibitor donepezil of the same magnitude occurred in the brain stem. The study was clearly too small to confirm group differences, but it suggests that 5-IA can be used to examine both group differences and treatment effects in patients with Alzheimer's disease.|
|Rights:||The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Alpha4beta2-nicotinic.pdf||273.59 kB||Adobe PDF||Under Permanent Embargo Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.