Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12179
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dc.contributor.authorRodriguez, Guidoen_UK
dc.contributor.authorMorbelli, Silviaen_UK
dc.contributor.authorBrugnolo, Andreaen_UK
dc.contributor.authorCalvini, Pieroen_UK
dc.contributor.authorGirtler, Nicolaen_UK
dc.contributor.authorPiccardo, Arnoldoen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.contributor.authorBaron, Jean-Claudeen_UK
dc.contributor.authorNobili, Flavioen_UK
dc.date.accessioned2014-09-15T20:30:30Z-
dc.date.available2014-09-15T20:30:30Zen_UK
dc.date.issued2005-10en_UK
dc.identifier.urihttp://hdl.handle.net/1893/12179-
dc.description.abstractPurpose: To examine the impact of severity of global cognitive impairment on SPECT-neuropsychology correlations, we correlated a verbal memory test with brain perfusion in patients with very mild Alzheimer's disease (AD), taking into account the Mini-Mental State Examination (MMSE) score as an index of global cognitive impairment. Methods: Twenty-nine outpatients (mean age 78.2±5.5 years) affected by very mild, probable AD underwent brain SPECT with 99mTc-ethylcysteinate dimer and a word list learning test. SPM99 was used for voxel-based correlation analysis after normalisation to mean cerebellar counts (height threshold: p less than 0.01). In a first analysis, only age and years of education were inserted as nuisance covariates, while in a second analysis the MMSE score was inserted as well. Results: In the first analysis, two clusters of significant correlation were found in both hemispheres, mainly including regions of the right hemisphere, such as the inferior parietal lobule, the middle temporal gyrus and the posterior cingulate. Significant correlation in the left hemisphere was observed in the lingual lobule, the parietal precuneus and the posterior cingulate. After taking into consideration the MMSE, the largest cluster of correlation was found in the left hemisphere, including the parietal gyrus angularis, the posterior cingulate and the middle temporal gyrus. Conclusion: The wide differences observed between the correlations achieved with and without taking into account the MMSE score indicate that severity of global cognitive impairment should be considered when searching for brain perfusion-neuropsychology correlations. In the present case, this strategy resulted in correlations that more closely matched neuropsychological models of verbal memory deficit.en_UK
dc.language.isoenen_UK
dc.publisherSpringeren_UK
dc.relationRodriguez G, Morbelli S, Brugnolo A, Calvini P, Girtler N, Piccardo A, Dougall N, Ebmeier KP, Baron J & Nobili F (2005) Global cognitive impairment should be taken into account in SPECT-neuropsychology correlations: the example of verbal memory in very mild Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging, 32 (10), pp. 1186-1192. https://doi.org/10.1007/s00259-005-1831-yen_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAlzheimer's diseaseen_UK
dc.subjectbrain SPECTen_UK
dc.subjectneuropsychologyen_UK
dc.subjectSPMen_UK
dc.subjectverbal learningen_UK
dc.subjectDementia therapyen_UK
dc.subjectAlzheimer Disease diagnosisen_UK
dc.subjectAlzheimer Disease therapyen_UK
dc.subjectCognition disordersen_UK
dc.titleGlobal cognitive impairment should be taken into account in SPECT-neuropsychology correlations: the example of verbal memory in very mild Alzheimer's diseaseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Global cognitive impairment.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1007/s00259-005-1831-yen_UK
dc.citation.jtitleEuropean Journal of Nuclear Medicine and Molecular Imagingen_UK
dc.citation.issn1619-7089en_UK
dc.citation.issn1619-7070en_UK
dc.citation.volume32en_UK
dc.citation.issue10en_UK
dc.citation.spage1186en_UK
dc.citation.epage1192en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailnadine.dougall@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Cambridgeen_UK
dc.contributor.affiliationUniversity of Genoaen_UK
dc.identifier.isiWOS:000232056300008en_UK
dc.identifier.scopusid2-s2.0-25144470105en_UK
dc.identifier.wtid713715en_UK
dc.contributor.orcid0000-0003-3462-6960en_UK
dcterms.dateAccepted2005-10-31en_UK
dc.date.filedepositdate2013-04-22en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorRodriguez, Guido|en_UK
local.rioxx.authorMorbelli, Silvia|en_UK
local.rioxx.authorBrugnolo, Andrea|en_UK
local.rioxx.authorCalvini, Piero|en_UK
local.rioxx.authorGirtler, Nicola|en_UK
local.rioxx.authorPiccardo, Arnoldo|en_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.authorBaron, Jean-Claude|en_UK
local.rioxx.authorNobili, Flavio|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameGlobal cognitive impairment.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1619-7070en_UK
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