Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12167
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dc.contributor.authorBrooks, Naomi-
dc.contributor.authorCloutier, Gregory-
dc.contributor.authorCadena, Samuel M-
dc.contributor.authorLayne, Jennifer E-
dc.contributor.authorNelsen, Carol A-
dc.contributor.authorFreed, Alicia M-
dc.contributor.authorRoubenoff, Ronenn-
dc.contributor.authorCastaneda-Sceppa, Carmen-
dc.date.accessioned2016-09-10T00:04:19Z-
dc.date.issued2008-07-
dc.identifier.urihttp://hdl.handle.net/1893/12167-
dc.description.abstractSpaceflight and bed rest (BR) result in losses of muscle mass and strength. Resistance training (RT) and amino acid (AA) supplementation are potential countermeasures to minimize these losses. However, it is unknown if timing of supplementation with exercise can optimize benefits, particularly with energy deficit. We examined the effect of these countermeasures on body composition, strength, and insulin levels in 31 men (ages 31-55 yr) during BR (28 days) followed by active recovery (14 days). Subjects were randomly assigned to essential AA supplementation (AA group, n = 7); RT with AA given 3 h after training (RT group, n = 12); or RT with AA given 5 min before training (AART group, n = 12). Energy intake was reduced by 8 +/- 6%. Midthigh muscle area declined with BR for the AA greater than RT greater than AART groups: -11%, -3%, -4% (P = 0.05). Similarly, greatest losses in lower body muscle strength were seen in the AA group (-22%). These were attenuated in the exercising groups [RT (-8%) and AART (-6%; P less than 0.05)]. Fat mass and midthigh intramuscular fat increased after BR in the AA group (+3% and +14%, respectively), and decreased in the RT (-5% and -4%) and AART groups (-1 and -5%; P = 0.05). Muscle mass and strength returned toward baseline after recovery, but the AA group showed the lowest regains. Combined resistance training with AA supplementation pre- or postexercise attenuated the losses in muscle mass and strength by approximately two-thirds compared with AA supplement alone during BR and energy deficit. These data support the efficacy of combined AA and RT as a countermeasure against muscle wasting due to low gravity.en_UK
dc.language.isoen-
dc.publisherAmerican Physiological Society-
dc.relationBrooks N, Cloutier G, Cadena SM, Layne JE, Nelsen CA, Freed AM, Roubenoff R & Castaneda-Sceppa C (2008) Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit, Journal of Applied Physiology, 105 (1), pp. 241-248.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectresistance exercise trainingen_UK
dc.subjectmuscle strengthen_UK
dc.subjectbody compositionen_UK
dc.subjectspaceflighten_UK
dc.subjectamino acid supplementationen_UK
dc.titleResistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficiten_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1152/japplphysiol.01346.2007-
dc.citation.jtitleJournal of Applied Physiology-
dc.citation.issn8750-7587-
dc.citation.volume105-
dc.citation.issue1-
dc.citation.spage241-
dc.citation.epage248-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailn.e.brooks@stir.ac.uk-
dc.contributor.affiliationSport-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationTufts University-
dc.contributor.affiliationNortheastern University (US)-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000257745900033-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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