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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: European Oncology Nursing Society extravasation guidelines
Author(s): Wengstrom, Yvonne
Margulies, Anita
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Keywords: Vesicants
Evidence-based practice
Intravenous therapy Complications
Drugs Side effects
Evidence-based medicine
Issue Date: Sep-2008
Date Deposited: 14-Apr-2009
Citation: Wengstrom Y & Margulies A (2008) European Oncology Nursing Society extravasation guidelines. European Journal of Oncology Nursing, 12 (4), pp. 357-361.;
Abstract: An infrequent, but potential complication of chemotherapy is vesicant chemotherapy extravasation. Vesicants have the potential to cause blistering and ulceration when they extravasate from the vein or are inadvertently administered into the tissue. In 2007, the European Oncology Nursing Society published guidelines for extravasation prevention, detection, and management. Recommended management includes topical heating for plant alkaloid extravasations and topical cooling for anthracycline and other antitumor antibiotic vesicants. For treatment of antracycline extravasations topical dimethylsulfoxide (DMSO), sodium thiosulfate, and hyaluronidase have been described in the literature but due to lack of evidence to support their use as vesicant extravasation antidotes, it is recommended that these agents are studied further. Furthermore, Savenes (dexrazoxane) is the only registered drug for the treatment of antracycline extravasation. Nurses need to be aware of current evidence-based guidelines for detecting and managing vesicant extravasations and need to be prepared to administer evidence-based treatment.
DOI Link: 10.1016/j.ejon.2008.07.003
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