Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/9855
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dc.contributor.authorShinn, Andrewen_UK
dc.contributor.authorPicon-Camacho, Sara Men_UK
dc.contributor.authorBron, Jamesen_UK
dc.contributor.authorConway, Dennyen_UK
dc.contributor.authorYoon, Gil Haen_UK
dc.contributor.authorGuo, Fu Cien_UK
dc.contributor.authorTaylor, Nicholas G Hen_UK
dc.date.accessioned2018-04-20T22:49:14Z-
dc.date.available2018-04-20T22:49:14Zen_UK
dc.date.issued2012-05-25en_UK
dc.identifier.urihttp://hdl.handle.net/1893/9855-
dc.description.abstractPycezeTM (Novartis Animal Vaccines Ltd.) is licensed as a veterinary medicine to treat fungal infections in salmon, trout and their eggs. The active ingredient is bronopol, which due to its broad-spectrum activity has the potential to be an effective treatment against other important aquatic pathogens. In this study the efficacy of bronopol against Ichthyophthirius multifiliis was tested both in vitro and in vivo. In vitro trials demonstrated a 30 min exposure to 100 mg L-1 bronopol killed 51.7% of the infective theronts. In vitro exposure of the protomonts to bronopol (0, 20, 50 and 100 mg L-1) for 30 min was observed to kill 0%, 76.2%, 97.2% and 100% respectively. Protomonts surviving treatment, demonstrated delayed development with the time taken from protomont until the release of theronts ranging from 28.3 h for 0 mg L-1 exposure, to 70 h for parasites in 20 and 50 mg L-1 exposure groups. These concentrations also caused asymmetric cell division of the encysted tomonts. Exposure of encysted tomonts (min. 8 cell stage) to 100 mg L-1 bronopol for 30 min, killed 50% within this period, with the remainder dying within the subsequent 42 h post exposure. Lower doses of bronopol were less effective in killing encysted tomonts than the higher doses (3.3% of parasites were killed in 20 mg L-1; 10% in 50 mg L-1), but they still delayed theront release significantly (25.7 h for 0 mg L-1 to 46.2 h for parasites exposed to 20-50 mg L-1). Long, low dose (1 mg L-1) exposure to bronopol was also efficacious against theronts. Survival after 12 h was 29% (c.f. 100% in control parasites), and less than 1% after 24 h exposure (c.f. 74% in control parasites). Theronts surviving these exposures demonstrated reduced infection success compared to control theronts. The findings of this study demonstrate that bronopol (PycezeTM) affects the survival of all free-living stages of I. multifiliis (protomonts, tomont and theronts), thus suggesting that bronopol may serve a useful role in the control of I. multifiliis infections.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationShinn A, Picon-Camacho SM, Bron J, Conway D, Yoon GH, Guo FC & Taylor NGH (2012) The anti-protozoal activity of bronopol on the key life-stages of Ichthyophthirius multifiliis Fouquet, 1876 (Ciliophora). Veterinary Parasitology, 186 (3-4), pp. 229-236. https://doi.org/10.1016/j.vetpar.2011.11.025en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectWhite spoten_UK
dc.subjectBronopolen_UK
dc.subjectPyceze™en_UK
dc.subjectTreatmenten_UK
dc.subjectManagementen_UK
dc.subjectAquacultureen_UK
dc.titleThe anti-protozoal activity of bronopol on the key life-stages of Ichthyophthirius multifiliis Fouquet, 1876 (Ciliophora)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-26en_UK
dc.rights.embargoreason[Shinn et al 2012 Vet Parasit Pyceze_1.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/j.vetpar.2011.11.025en_UK
dc.identifier.pmid22153260en_UK
dc.citation.jtitleVeterinary Parasitologyen_UK
dc.citation.issn0304-4017en_UK
dc.citation.volume186en_UK
dc.citation.issue3-4en_UK
dc.citation.spage229en_UK
dc.citation.epage236en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emaila.p.shinn@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNovartis UKen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.identifier.isiWOS:000304336400011en_UK
dc.identifier.scopusid2-s2.0-84858079344en_UK
dc.identifier.wtid888987en_UK
dc.contributor.orcid0000-0002-5434-2685en_UK
dc.contributor.orcid0000-0003-3544-0519en_UK
dcterms.dateAccepted2012-05-25en_UK
dc.date.filedepositdate2012-10-25en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorShinn, Andrew|0000-0002-5434-2685en_UK
local.rioxx.authorPicon-Camacho, Sara M|en_UK
local.rioxx.authorBron, James|0000-0003-3544-0519en_UK
local.rioxx.authorConway, Denny|en_UK
local.rioxx.authorYoon, Gil Ha|en_UK
local.rioxx.authorGuo, Fu Ci|en_UK
local.rioxx.authorTaylor, Nicholas G H|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2999-12-26en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameShinn et al 2012 Vet Parasit Pyceze_1.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0304-4017en_UK
Appears in Collections:Aquaculture Journal Articles

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