Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/9199
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLonie, Jane Aen_UK
dc.contributor.authorParra-Rodriguez, Mario Aen_UK
dc.contributor.authorTierney, Kevin Men_UK
dc.contributor.authorHerrmann, Lucie Len_UK
dc.contributor.authorDonaghey, Claireen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.date.accessioned2013-06-08T20:03:40Z-
dc.date.available2013-06-08T20:03:40Z-
dc.date.issued2010-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/9199-
dc.description.abstractBackground: Cognitive impairment precedes the diagnosis of Alzheimer's disease. It is unclear which psychometric measures predict dementia, and what cut-off points should be used. Replicable cognitive measures to provide information about differential diagnosis and prognosis would be clinically useful. Aims: In a prospective cohort study we investigated which measures distinguish between individuals with amnestic mild cognitive impairment (aMCI) that converts to dementia and those whose impairment does not, and which combination of measures best predicts the fate of people with aMCI. Method: Forty-four participants with aMCI underwent extensive neuropsychological assessment at baseline and annually thereafter for an average of 4 years. Differences in baseline cognitive performance of participants who were converters and non-converters to clinically diagnosed dementia were analysed. Classification accuracy was estimated by sensitivity, specificity, positive and negative predictive values and using logistic regression. Results: Forty-one percent of participants had progressed to dementia by the end of study, with a mean annual conversion rate of 11%. Most (63%) showed persisting or progressive cognitive impairment, irrespective of diagnosis. The Addenbrooke's Cognitive Examination together with the discrimination index of the Hopkins Verbal Learning Test - Revised (but none of the demographic indices) differentiated the participants who were converters from the non-converters at baseline with 74% accuracy. Conclusions: Targeted neuropsychological assessment, beyond simple cognitive screening, could be used in clinical practice to provide individuals with aMCI with prognostic information and aid selective early initiation of monitoring and treatment among those who progress towards a clinically diagnosable dementia.en_UK
dc.language.isoenen_UK
dc.publisherThe Royal College of Psychiatristsen_UK
dc.relationLonie JA, Parra-Rodriguez MA, Tierney KM, Herrmann LL, Donaghey C, O'Carroll R & Ebmeier KP (2010) Predicting outcome in mild cognitive impairment: 4-Year follow-up study. British Journal of Psychiatry, 197 (2), pp. 135-140. https://doi.org/10.1192/bjp.bp.110.077958en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titlePredicting outcome in mild cognitive impairment: 4-Year follow-up studyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[ocarroll_BJP_2010.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1192/bjp.bp.110.077958en_UK
dc.citation.jtitleBritish Journal of Psychiatryen_UK
dc.citation.issn1472-1465en_UK
dc.citation.issn0007-1250en_UK
dc.citation.volume197en_UK
dc.citation.issue2en_UK
dc.citation.spage135en_UK
dc.citation.epage140en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailronan.ocarroll@stir.ac.uken_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000280896100010en_UK
dc.identifier.scopusid2-s2.0-77955370974en_UK
dc.identifier.wtid765025en_UK
dc.contributor.orcid0000-0002-5130-291Xen_UK
dcterms.dateAccepted2010-08-31en_UK
dc.date.filedepositdate2012-09-24en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorLonie, Jane A|en_UK
local.rioxx.authorParra-Rodriguez, Mario A|en_UK
local.rioxx.authorTierney, Kevin M|en_UK
local.rioxx.authorHerrmann, Lucie L|en_UK
local.rioxx.authorDonaghey, Claire|en_UK
local.rioxx.authorO'Carroll, Ronan|0000-0002-5130-291Xen_UK
local.rioxx.authorEbmeier, Klaus P|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameocarroll_BJP_2010.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0007-1250en_UK
Appears in Collections:Psychology Journal Articles

Files in This Item:
File Description SizeFormat 
ocarroll_BJP_2010.pdfFulltext - Published Version341.2 kBAdobe PDFUnder Embargo until 3000-01-01    Request a copy


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.