Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8860
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans
Authors: Biolo, Gianni
Maggi, Sergio P
Williams, Bradley D
Tipton, Kevin
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: PHENYLALANINE
PROTEIN SYNTHESIS
MUSCLE BIOPSY
ARTERIOVENOUS BALANCE
Issue Date: Mar-1995
Publisher: American Physiological Society
Citation: Biolo G, Maggi SP, Williams BD, Tipton K & Wolfe RR (1995) Increased rates of muscle protein turnover and amino acid transport after resistance exercise in humans, American Journal of Physiology - Endocrinology and Metabolism, 268 (3), pp. E514-E520.
Abstract: The rates of protein synthesis and degradation and of amino acid transport were determined in the leg muscle of untrained postabsorptive normal volunteers at rest and approximately 3 h after a resistance exercise routine. The methodology involved use of stable isotopic tracers of amino acids, arteriovenous catheterization of the femoral vessels, and biopsy of the vastus lateralis muscle. During postexercise recovery, the rate of intramuscular phenylalanine utilization for protein synthesis increased above the basal value by 108 +/- 18%, whereas the rate of release from proteolysis increased by 51 +/- 17%. Muscle protein balance improved (P less than 0.05) after exercise but did not become positive (from -15 +/- 12 to -6 +/- 3 nmol phenylalanine.min-1.100 ml leg volume-1). After exercise, rates of inward transport of leucine, lysine, and alanine increased (P less than 0.05) above the basal state from 132 +/- 16 to 208 +/- 29, from 122 +/- 8 to 260 +/- 8, and from 384 +/- 71 to 602 +/- 89 nmol.min-1.100 ml leg-1, respectively. Transport of phenylalanine did not change significantly. These results indicate that, during recovery after resistance exercise, muscle protein turnover is increased because of an acceleration of synthesis and degradation. A postexercise acceleration of amino acid transport may contribute to the relatively greater stimulation of protein synthesis.
Type: Journal Article
URI: http://hdl.handle.net/1893/8860
URL: http://ajpendo.physiology.org/content/268/3/E514.abstract
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
Sport
University of Texas

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