Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8853
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Do H-2-receptor antagonists cause acute pancreatitis?
Authors: Evans, Josie
McMahon, Alex D
Steinke, Douglas T
McAlpine, Ritchie R
MacDonald, Thomas M
Contact Email: josie.evans@stir.ac.uk
Keywords: automated database
case-control study
H-2-receptor antagonists
pancreatitis
confounding
Issue Date: Dec-1998
Publisher: Wiley and Sons
Citation: Evans J, McMahon AD, Steinke DT, McAlpine RR & MacDonald TM (1998) Do H-2-receptor antagonists cause acute pancreatitis?, Pharmacoepidemiology and Drug Safety, 7 (6), pp. 383-388.
Abstract: The aim of this study was to investigate the association between H(2)-receptor antagonists and acute pancreatitis. The automated database of the Medicines Monitoring Unit (MEMO) was used to carry out a case-control study, supplemented with information on possible confounding factors from hospital and GP medical records. Cases were patients hospitalized with a computerized diagnosis of acute pancreatitis, and two sets of controls were drawn from (1) the study population and from (2) the same GP practice as the case. Current or 60-day exposure to cimetidine and ranitidine was analysed. In adjusted analyses, cimetidine exposure and ranitidine exposure were associated with an increased risk of hospitalization for acute pancreatitis, as were alcohol abuse and cholelithiasis. The risks were lower in unadjusted analyses, suggesting that the association is confounded, although they did not disappear completely. A possible explanation is that data on confounding were incomplete. This study cannot discount the existence of an association between H(2)-antagonists and acute pancreatitis, and highlights the difficulties involved in obtaining complete and accurate data on confounding factors that are not collected routinely.
Type: Journal Article
URI: http://hdl.handle.net/1893/8853
URL: http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1099-1557(199811/12)7:6%3C383::AID-PDS377%3E3.0.CO;2-Q/abstract
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: HS Research - Stirling
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Medicines Monitoring Unit (MEMO)
Ninewells Hospital & Medical School

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