Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8800
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure
Authors: Evans, Josie
McGregor, Ellon
McMahon, Alex D
McGilchrist, Mark M
Jones, Martyn C
White, G
McDevitt, Denis G
MacDonald, Thomas M
Contact Email: josie.evans@stir.ac.uk
Issue Date: Aug-1995
Publisher: Oxford University Press
Citation: Evans J, McGregor E, McMahon AD, McGilchrist MM, Jones MC, White G, McDevitt DG & MacDonald TM (1995) Non-steroidal anti-inflammatory drugs and hospitalization for acute renal failure, QJM, 88 (8), pp. 551-557.
Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have been implicated in the aetiology of acute renal failure (ARF), but epidemiological studies examining this association have produced disparate results. We conducted a case-control study using a purposebuilt record-linkage database for a population of 420 600 patients, resident in Tayside since May 1990. Patients (n = 207) hospitalized with a diagnostic code for ARF between 1990 and 1992 had their diagnosis validated by a renal physician. Six community controls and two hospital controls, matched for age and sex, were generated for each of these cases. Exposure to dispensed oral NSAIDs, topical NSAIDs and aspirin during the 90 days prior to the index date were investigated (recent exposure), as was exposure at any time since January 1989 (previous exposure). The most significant associations were modelled using conditional logistic regression. When community controls were used, recent exposure to NSAIDs and previous exposure to aspirin were independently associated with hospitalization for ARF, with adjusted odds ratios of 2.20 (1.49-3.25) and 2.19 (1.46-3.30), respectively. Only recent exposure to oral NSAIDs was associated when hospital controls were used: 1.84 (1.14-2.93). No significant interactions were present with previous chronic renal failure, other possible causes of ARF or whether the diagnosis was primary or secondary. There is an approximate doubling of the risk of hospitalization for ARF with use of oral NSAIDs.
Type: Journal Article
URI: http://hdl.handle.net/1893/8800
URL: http://qjmed.oxfordjournals.org/content/88/8/551.abstract
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: HS Research - Stirling
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
University of Dundee
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School

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