Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8799
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease
Authors: Evans, Josie
McMahon, Alex
Murray, Frank E
McDevitt, Denis G
MacDonald, Thomas M
Contact Email: josie.evans@stir.ac.uk
Keywords: Ulcerative colitis
Crohn's colitis
Colitis
NSAIDs
Case-control study
Issue Date: May-1997
Publisher: BMJ Publishing Group / British Society of Gastroenterology (BSG)
Citation: Evans J, McMahon A, Murray FE, McDevitt DG & MacDonald TM (1997) Non-steroidal anti-inflammatory drugs are associated with emergency admission to hospital for colitis due to inflammatory bowel disease, Gut, 40 (5), pp. 619-622.
Abstract: Background - To evaluate the relation between non-steroidal anti-inflammatory drugs (NSAIDs) and colitis due to inflammatory bowel disease. Methods - A case-control study was conducted using a prospectively constructed, record linkage database containing hospital event and dispensed drug data (1989-93). The study population consisted of 319,465 people resident in Tayside in January 1989, and still resident (or dead) in October 1994. Results - Of the 785 patients admitted to hospital as emergencies with colitis between July 1989 and June 1993, 200 fulfilled the case criterion of colitis due to inflammatory bowel disease. A further 1,198 persons were used as community controls. Odds ratios were calculated for three exposure periods (current, recent, and past exposure). The overall odds ratios (with 95% confidence intervals) for current and recent exposure to NSAIDs were 1.77 (1.01 to 3.10) and 1.93 (1.20 to 3.09) respectively. Current and recent exposure to NSAIDs was also associated for incident cases, with odds ratios of 2.96 (1.32 to 6.64) and 2.51 (1.13 to 5.55). There was a trend for recent exposure among non-incident cases. Conclusion - The use of NSAIDs may be associated with an increased risk of emergency admission to hospital for colitis due to inflammatory bowel disease, particularly among patients with no previous history.
Type: Journal Article
URI: http://hdl.handle.net/1893/8799
URL: http://gut.bmj.com/content/40/5/619.abstract
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: HS Research - Stirling
ASS Management and Support Team
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School

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