Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8798
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: No association between non-steroidal anti-inflammatory drugs and acute appendicitis in a case-control study
Authors: Evans, Josie
MacGregor, Ailsa M
Murray, Frank E
Vaidya, Kishor S
Morris, Andrew D
MacDonald, Thomas M
Contact Email: josie.evans@stir.ac.uk
Issue Date: Mar-1997
Publisher: John Wiley and Sons for the British Journal of Surgery Society
Citation: Evans J, MacGregor AM, Murray FE, Vaidya KS, Morris AD & MacDonald TM (1997) No association between non-steroidal anti-inflammatory drugs and acute appendicitis in a case-control study, British Journal of Surgery, 84 (3), pp. 372-374.
Abstract: Background: A recent case-control study reported an association between non-steroidal antiinflammatory drug (NSAID) use and acute appendicitis. This association was investigated in a case-control study of patients, aged 30 years and over, admitted as an emergency to hospitals in Tayside between 1989 and 1992, who had appendicectomy for acute appendicitis. Methods: A record-linkage database containing records of dispensed prescriptions and hospital admissions was used. A total of 223 patients were identified. The medical records of 161 were checked, of which 138 were valid cases, and information on white cell count and NSAID exposure was recorded. Community and hospital controls were generated. Results: Some 9.0 per cent of patients were prescribed NSAIDs within 90 days of hospitalization, compared with 7.6 per cent of community controls and 11.5 per cent of hospital controls. The odds ratio was 1.21 (95 per cent confidence interval 0.73-2.01) and 0.75 (0.43-1.32) respectively. There was no significant difference in white cell count between exposed and non-exposed cases. No increased risk of appendicectomy was associated with aspirin use: odds ratio 1.67 (052-5.30) and 0.37 (0.1 2-1.13) using community and hospital controls respectively. Conclusion: Appendicectomy for acute appendicitis is not associated with increased prior use of NSAIDs.
Type: Journal Article
URI: http://hdl.handle.net/1893/8798
URL: http://www.bjs.co.uk/details/article/904005/No-association-between-nonsteroidal-antiinflammatory-drugs-and-acute-appendiciti.html
DOI Link: http://dx.doi.org/10.1046/j.1365-2168.1997.02575.x
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: HS Research - Stirling
University of Dundee
Ninewells Hospital & Medical School
University of Dundee
University of Dundee
Ninewells Hospital & Medical School

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