Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8793
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma?
Authors: Ellis, John D
Evans, Josie
Ruta, Danny A
Baines, Paul S
Leese, Graham
MacDonald, Thomas M
Morris, Andrew D
Contact Email: josie.evans@stir.ac.uk
Issue Date: Nov-2000
Publisher: BMJ Publishing Group
Citation: Ellis JD, Evans J, Ruta DA, Baines PS, Leese G, MacDonald TM & Morris AD (2000) Glaucoma incidence in an unselected cohort of diabetic patients: is diabetes mellitus a risk factor for glaucoma?, British Journal of Ophthalmology, 84 (11), pp. 1218-1224.
Abstract: Aims - To evaluate whether diabetes mellitus is a risk factor for the development of primary open angle glaucoma or ocular hypertension (OHT). Methods - A historical cohort study of an unselected population comprising all residents of the Tayside region of Scotland was performed using record linkage techniques followed by case note review. Ascertainment of prevalent diabetes was achieved using the Diabetes Audit and Research in Tayside Study (DARTS) validated regional diabetes register. Glaucoma and treated OHT were defined by encashment of community prescriptions and the statutory surgical procedure coding database. Results - The study population comprised 6,631 diabetic subjects and 166,144 nondiabetic subjects aged less than 40 years without glaucoma or OHT at study entry. 65 patients with diabetes and 958 without diabetes were identified as new cases of glaucoma or treated OHT during the 24 month study period, yielding a standardised morbidity ratio of 127 (95% CI, 96-158). Case note review demonstrated non-differential misclassification of prevalent glaucoma and OHT as incident disease (diabetic cohort 20%, non-diabetic cohort 24%; p=0.56) primarily as a result of non-compliance in medically treated disease. Removing misclassified cases and adjusting for age yielded an incidence of primary open angle glaucoma in diabetes of 1.1/1000 patient years (95% CI, 0.89- 1.31) compared to 0.7/1000 patient years (95% CI, 0.54-0.86) in the non-diabetic cohort; RR 1.57 (95% CI, 0.99-2.48). Conclusions - This study failed to confirm an association between diabetes mellitus and primary open angle glaucoma and ocular hypertension. A non-significant increase in diagnosed and treated disease in the diabetic population was observed, but evidence was also found that detection bias contributes to this association.
Type: Journal Article
URI: http://hdl.handle.net/1893/8793
DOI Link: http://dx.doi.org/10.1136/bjo.84.11.1218
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Ninewells Hospital & Medical School
HS Research - Stirling
University of Dundee
Ninewells Hospital & Medical School
University of Dundee
Ninewells Hospital & Medical School
University of Dundee

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