Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8782
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation
Authors: McMahon, Alex
Evans, Josie
White, G
Murray, Frank E
McGilchrist, Mark M
McDevitt, Denis G
MacDonald, Thomas M
Contact Email: josie.evans@stir.ac.uk
Keywords: Cohort
Epidemiology
Re-sampling
NSAID
Hemorrhage
Perforation
Issue Date: Mar-1997
Publisher: Elsevier
Citation: McMahon A, Evans J, White G, Murray FE, McGilchrist MM, McDevitt DG & MacDonald TM (1997) A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation, Journal of Clinical Epidemiology, 50 (3), pp. 351-356.
Abstract: This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).
Type: Journal Article
URI: http://hdl.handle.net/1893/8782
DOI Link: http://dx.doi.org/10.1016/S0895-4356(96)00361-7
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: ASS Management and Support Team
HS Research - Stirling
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School
Ninewells Hospital & Medical School

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