Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8740
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Towards a computational model for-1 eukaryotic frameshifting sites
Authors: Bekaert, Michaël
Bidou, Laure
Denise, Alain
Duchateau-Nguyen, Guillemette
Forest, Jean-Paul
Froidevaux, Christine
Hatin, Isabelle
Rousset, Jean-Pierre
Termier, Michel
Contact Email: michael.bekaert@stir.ac.uk
Issue Date: 12-Feb-2003
Publisher: Oxford University Press
Citation: Bekaert M, Bidou L, Denise A, Duchateau-Nguyen G, Forest J, Froidevaux C, Hatin I, Rousset J & Termier M (2003) Towards a computational model for-1 eukaryotic frameshifting sites, Bioinformatics, 19 (3), pp. 327-335.
Abstract: Motivation: Unconventional decoding events are now well acknowledged, but not yet well formalized. In this study, we present a bioinformatics analysis of eukaryotic −1 frameshifting, in order to model this event. Results: A consensus model has already been established for -1 frameshifting sites. Our purpose here is to provide new constraints which make the model more precise. We show how a machine learning approach can be used to refine the current model. We identify new properties that may be involved in frameshifting. Each of the properties found was experimentally validated. Initially, we identify features of the overall model that are to be simultaneously satisfied. We then focus on the following two components: the spacer and the slippery sequence. As a main result, we point out that the identity of the primary structure of the so-called spacer is of great importance.
Type: Journal Article
URI: http://hdl.handle.net/1893/8740
DOI Link: http://dx.doi.org/10.1093/bioinformatics/btf868
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
Institute of Genetics and Microbiology, France
Institute of Genetics and Microbiology, France
Institute of Genetics and Microbiology, France
University of Paris 11 (University of Paris Sud)
University of Paris 11 (University of Paris Sud)
Institute of Genetics and Microbiology, France
Institute of Genetics and Microbiology, France
Institute of Genetics and Microbiology, France

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