Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8735
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Antibacterial free fatty acids: Activities, mechanisms of action and biotechnological potential
Authors: Desbois, Andrew P
Smith, Valerie J
Contact Email: andrew.desbois@stir.ac.uk
Keywords: Antibiotic - Antimicrobial - Drug resistance - Lipid - Natural products
Issue Date: Feb-2010
Publisher: Springer
Citation: Desbois AP & Smith VJ (2010) Antibacterial free fatty acids: Activities, mechanisms of action and biotechnological potential, Applied Microbiology and Biotechnology, 85 (6), pp. 1629-1642.
Abstract: Amongst the diverse and potent biological activities of free fatty acids (FFAs) is the ability to kill or inhibit the growth of bacteria. The antibacterial properties of FFAs are used by many organisms to defend against parasitic or pathogenic bacteria. Whilst their antibacterial mode of action is still poorly understood, the prime target of FFA action is the cell membrane, where FFAs disrupt the electron transport chain and oxidative phosphorylation. Besides interfering with cellular energy production, FFA action may also result from the inhibition of enzyme activity, impairment of nutrient uptake, generation of peroxidation and auto-oxidation degradation products or direct lysis of bacterial cells. Their broad spectrum of activity, non-specific mode of action and safety makes them attractive as antibacterial agents for various applications in medicine, agriculture and food preservation, especially where the use of conventional antibiotics is undesirable or prohibited. Moreover, the evolution of inducible FFA-resistant phenotypes is less problematic than with conventional antibiotics. The potential for commercial or biomedical exploitation of antibacterial FFAs, especially for those from natural sources, is discussed.
Type: Journal Article
URI: http://hdl.handle.net/1893/8735
DOI Link: http://dx.doi.org/10.1007/s00253-009-2355-3
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of St Andrews

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