Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8734
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: A fatty acid from the diatom Phaeodactylum tricornutum is antibacterial against diverse bacteria including multi-resistant Staphylococcus aureus (MRSA)
Authors: Desbois, Andrew P
Mearns-Spragg, Andrew
Smith, Valerie J
Contact Email: andrew.desbois@stir.ac.uk
Keywords: Antimicrobial
Drug resistance
Eicosapentaenoic acid
Microalga
Natural products
Issue Date: Feb-2009
Publisher: Springer
Citation: Desbois AP, Mearns-Spragg A & Smith VJ (2009) A fatty acid from the diatom Phaeodactylum tricornutum is antibacterial against diverse bacteria including multi-resistant Staphylococcus aureus (MRSA), Marine Biotechnology, 11 (1), pp. 45-52.
Abstract: Pathogenic bacteria, such as multidrug-resistant Staphylococcus aureus (MRSA), which are not susceptible to most conventional antibiotics, are causing increased concern in healthcare institutions worldwide. The discovery of novel antibacterial compounds for biomedical exploitation is one avenue that is being pursued to combat these problematic bacteria. Marine eukaryotic microalgae are known to produce numerous useful products but have attracted little attention in the search for novel antibiotic compounds. Cell lysates of the marine diatom, Phaeodactylum tricornutum Bohlin, have been reported to display antibacterial activity in vitro, but the compounds responsible have not been fully identified. In this paper, using column chromatography and reversed-phase high-performance liquid chromatography, we report the isolation of an antibacterial fatty acid. Mass spectrometry and 1H-nuclear magnetic resonance spectroscopy revealed it to be the polyunsaturated fatty acid, eicosapentaenoic acid (EPA). We show that EPA is active against a range of both Gram-positive and Gram-negative bacteria, including MRSA, at micromolar concentrations. These data indicate that it could find application in the topical and systemic treatment of drug-resistant bacterial infections.
Type: Journal Article
URI: http://hdl.handle.net/1893/8734
URL: http://www.scopus.com/inward/record.url?partnerID=yv4JPVwI&eid=2-s2.0-58849167639&md5=51ad937a5959ac9be96612241b663387
DOI Link: http://dx.doi.org/10.1007/s10126-008-9118-5
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
Dunstaffnage Marine Laboratory
University of St Andrews

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