Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/8733
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Bactericidal synergy of lysostaphin in combination with antimicrobial peptides
Authors: Desbois, Andrew P
Coote, Peter J
Contact Email: andrew.desbois@stir.ac.uk
Issue Date: Aug-2011
Publisher: Springer
Citation: Desbois AP & Coote PJ (2011) Bactericidal synergy of lysostaphin in combination with antimicrobial peptides, European Journal of Clinical Microbiology and Infectious Diseases, 30 (8), pp. 1015-1021.
Abstract: Drug-resistant staphylococci constitute a serious problem that urgently requires the discovery of new therapeutic agents. There has been a resurgence in interest in using lysostaphin (a specific anti-staphylococcal enzyme) as a treatment for infections caused by these important pathogens. However, bacterial resistance to lysostaphin is a problem, but the use of a combination treatment may surmount this issue. In this present study, using viable counts from suspension incubations, lysostaphin is shown to be synergistically bactericidal in combination with various conventional antimicrobial peptides, the antimicrobial protein bovine lactoferrin, a lantibiotic (nisin), and certain lipopeptides used clinically (colistin, daptomycin and polymyxin B). Combinations that act in synergy are of clinical importance as these reduce the doses of the compounds needed for effective treatments and decrease the chances of resistance being selected. The use of lysostaphin in combination with a peptide may represent a new avenue in tackling drug-resistant staphylococci.
Type: Journal Article
URI: http://hdl.handle.net/1893/8733
DOI Link: http://dx.doi.org/10.1007/s10096-011-1188-z
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of St Andrews

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