|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Postexercise net protein synthesis in human muscle from orally administered amino acids|
Ferrando, Arny A
Phillips, Stuart M
Doyle, David J
Wolfe, Robert R
|Keywords:||muscle protein synthesis|
muscle protein breakdown
|Citation:||Tipton K, Ferrando AA, Phillips SM, Doyle DJ & Wolfe RR (1999) Postexercise net protein synthesis in human muscle from orally administered amino acids, American Journal of Physiology - Endocrinology and Metabolism, 276 (4), pp. E628-E634.|
|Abstract:||We examined the response of net muscle protein synthesis to ingestion of amino acids after a bout of resistance exercise. A primed, constant infusion ofl-[ring-2H5]phenylalanine was used to measure net muscle protein balance in three male and three female volunteers on three occasions. Subjects consumed in random order 1 liter of 1) a mixed amino acid (40 g) solution (MAA), 2) an essential amino acid (40 g) solution (EAA), and3) a placebo solution (PLA). Arterial amino acid concentrations increased ∼150-640% above baseline during ingestion of MAA and EAA. Net muscle protein balance was significantly increased from negative during PLA ingestion (-50 ± 23 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) to positive during MAA ingestion (17 ± 13 nmol ⋅ min-1 ⋅ 100 ml leg volume-1) and EAA (29 ± 14 nmol ⋅ min-1 ⋅ 100 ml leg volume-1;P less than 0.05). Because net balance was similar for MAA and EAA, it does not appear necessary to include nonessential amino acids in a formulation designed to elicit an anabolic response from muscle after exercise. We concluded that ingestion of oral essential amino acids results in a change from net muscle protein degradation to net muscle protein synthesis after heavy resistance exercise in humans similar to that seen when the amino acids were infused.|
|Rights:||The publisher has not responded to our queries therefore this work cannot be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|E628.full.pdf||207.75 kB||Adobe PDF||Under Embargo until 31/12/2999 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.