Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7682
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver
Authors: Pirrit, Lindsay A
Healey, R
Assheton, H
Leaver, Michael
George, Stephen
Contact Email: m.j.leaver@stir.ac.uk
Issue Date: 1995
Publisher: Elsevier
Citation: Pirrit LA, Healey R, Assheton H, Leaver M & George S (1995) Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver, Marine Environmental Research, 39 (1-4), pp. 15-19.
Abstract: cDNA's coding for cytochrome P4501A1 (CYP1A1), phenol UDP- glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST-A) were cloned and sequenced from an expression library prepared from the liver of a 3- methylcholanthrene (3-MC) induced plaice. Plaice CYP1A1 and Phenol UDPGT display a high degree of structural conservation with homologous mammalian isoforms and their mRNAs were shown to be highly induced in liver after 3-MC treatment of fish. Expression of plaice GST-A, which displays closer homology to GSTs from plants and invertebrates than those of mammals, is repressed after 3-MC treatment.
Type: Journal Article
URI: http://hdl.handle.net/1893/7682
URL: http://www.sciencedirect.com/science/article/pii/014111369400065W
DOI Link: http://dx.doi.org/10.1016/0141-1136(94)00065-W
Rights: The publisher has not responded to our queries therefore this work cannot be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Stirling
University of Stirling
University of Stirling
Aquaculture
Aquaculture

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