|Appears in Collections:||Aquaculture Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver|
|Authors:||Pirrit, Lindsay A|
|Citation:||Pirrit LA, Healey R, Assheton H, Leaver M & George S (1995) Cloning of the major 3-MC inducible phase I and phase II detoxification enzymes of plaice liver, Marine Environmental Research, 39 (1-4), pp. 15-19.|
|Abstract:||cDNA's coding for cytochrome P4501A1 (CYP1A1), phenol UDP- glucuronosyltransferase (UDPGT) and glutathione S-transferase (GST-A) were cloned and sequenced from an expression library prepared from the liver of a 3- methylcholanthrene (3-MC) induced plaice. Plaice CYP1A1 and Phenol UDPGT display a high degree of structural conservation with homologous mammalian isoforms and their mRNAs were shown to be highly induced in liver after 3-MC treatment of fish. Expression of plaice GST-A, which displays closer homology to GSTs from plants and invertebrates than those of mammals, is repressed after 3-MC treatment.|
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