Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7637
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Essential amino acids and muscle protein recovery from resistance exercise
Authors: Borsheim, Elisabet
Tipton, Kevin
Wolf, Steven E
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: muscle protein metabolism
essential amino acids
stable isotopes
Issue Date: Oct-2002
Publisher: The American Physiological Society
Citation: Borsheim E, Tipton K, Wolf SE & Wolfe RR (2002) Essential amino acids and muscle protein recovery from resistance exercise, American Journal of Physiology - Endocrinology and Metabolism, 283 (4), pp. E648-E657.
Abstract: This study tests the hypothesis that a dose of 6 g of orally administered essential amino acids (EAAs) stimulates net muscle protein balance in healthy volunteers when consumed 1 and 2 h after resistance exercise. Subjects received a primed constant infusion ofl-[2H5]phenylalanine andl-[1-13C]leucine. Samples from femoral artery and vein and biopsies from vastus lateralis were obtained. Arterial EAA concentrations increased severalfold after drinks. Net muscle protein balance (NB) increased proportionally more than arterial AA concentrations in response to drinks, and it returned rapidly to basal values when AA concentrations decreased. Area under the curve for net phenylalanine uptake above basal value was similar for the first hour after each drink (67 ± 17 vs. 77 ± 20 mg/leg, respectively). Because the NB response was double the response to two doses of a mixture of 3 g of EAA + 3 g of nonessential AA (NEAA) (14), we conclude that NEAA are not necessary for stimulation of NB and that there is a dose-dependent effect of EAA ingestion on muscle protein synthesis.
Type: Journal Article
URI: http://hdl.handle.net/1893/7637
URL: http://ajpendo.physiology.org/content/283/4/E648.full
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Texas Medical Branch
Sport
University of Texas Medical Branch
University of Texas

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