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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise
Authors: Rasmussen, Blake B
Tipton, Kevin
Miller, Sharon L
Wolf, Steven E
Wolfe, Robert R
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Keywords: muscle protein synthesis
stable isotopes
nutritional supplementation
Issue Date: Feb-2000
Publisher: The American Physiological Society
Citation: Rasmussen BB, Tipton K, Miller SL, Wolf SE & Wolfe RR (2000) An oral essential amino acid-carbohydrate supplement enhances muscle protein anabolism after resistance exercise, Journal of Applied Physiology, 88 (2), pp. 386-392.
Abstract: This study was designed to determine the response of muscle protein to the bolus ingestion of a drink containing essential amino acids and carbohydrate after resistance exercise. Six subjects (3 men, 3 women) randomly consumed a treatment drink (6 g essential amino acids, 35 g sucrose) or a flavored placebo drink 1 h or 3 h after a bout of resistance exercise on two separate occasions. We used a three-compartment model for determination of leg muscle protein kinetics. The model involves the infusion of ring-2H5-phenylalanine, femoral arterial and venous blood sampling, and muscle biopsies. Phenylalanine net balance and muscle protein synthesis were significantly increased above the predrink and corresponding placebo value (P less than 0.05) when the drink was taken 1 or 3 h after exercise but not when the placebo was ingested at 1 or 3 h. The response to the amino acid-carbohydrate drink produced similar anabolic responses at 1 and 3 h. Muscle protein breakdown did not change in response to the drink. We conclude that essential amino acids with carbohydrates stimulate muscle protein anabolism by increasing muscle protein synthesis when ingested 1 or 3 h after resistance exercise.
Type: Journal Article
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas

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