Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7626
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dc.contributor.authorLeaver, Michaelen_UK
dc.contributor.authorBoukouvala, Evridikien_UK
dc.contributor.authorAntonopoulou, Efthimiaen_UK
dc.contributor.authorDiez, Amaliaen_UK
dc.contributor.authorFavre-Krey, Laurenceen_UK
dc.contributor.authorEzaz, M Tariqen_UK
dc.contributor.authorBautista, Jose Men_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorKrey, Grigoriosen_UK
dc.date.accessioned2012-08-27T08:09:28Z-
dc.date.available2012-08-27T08:09:28Z-
dc.date.issued2005-07en_UK
dc.identifier.urihttp://hdl.handle.net/1893/7626-
dc.description.abstractThe cloning and characterization of cDNAs and genes encoding three peroxisome proliferator-activated receptor (PPAR) isotypes from two species of marine fish, the plaice (Pleuronectes platessa) and the gilthead sea bream (Sparus aurata), are reported for the first time. Although differences in the genomic organization of the fish PPAR genes compared with their mammalian counterparts are evident, sequence alignments and phylogenetic comparisons show the fish genes to be homologs of mammalian PPARα, PPARβ/δ, and PPARγ. Like their mammalian homologs, fish PPARs bind to a variety of natural PPAR response elements (PPREs) present in the promoters of mammalian or piscine genes. In contrast, the mRNA expression pattern of PPARs in the two fish species differs from that observed in other vertebrates. Thus, PPARγ is expressed more widely in fish tissues than in mammals, whereas PPARα and β are expressed similarly in profile to mammals. Furthermore, nutritional status strongly influences the expression of all three PPAR isotypes in liver, whereas it has no effect on PPAR expression in intestinal and adipose tissues. Fish PPARα and β exhibit an activation profile similar to that of the mammalian PPAR in response to a variety of activators/ligands, whereas PPARγ is not activated by mammalian PPARγ-specific ligands. Amino acid residues shown to be critical for ligand binding in mammalian PPARs are not conserved in fish PPARγ and therefore, together with the distinct tissue expression profile of this receptor, suggest potential differences in the function of PPARγ in fish compared with mammals.en_UK
dc.language.isoenen_UK
dc.publisherThe Endocrine Societyen_UK
dc.relationLeaver M, Boukouvala E, Antonopoulou E, Diez A, Favre-Krey L, Ezaz MT, Bautista JM, Tocher DR & Krey G (2005) Three peroxisome proliferator-activated receptor isotypes from each of two species of marine fish. Endocrinology, 146 (7), pp. 3150-3162. https://doi.org/10.1210/en.2004-1638en_UK
dc.rightsPublisher policy allows this work to be made available in this repository.en_UK
dc.titleThree peroxisome proliferator-activated receptor isotypes from each of two species of marine fishen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1210/en.2004-1638en_UK
dc.citation.jtitleEndocrinologyen_UK
dc.citation.issn1945-7170en_UK
dc.citation.issn0013-7227en_UK
dc.citation.volume146en_UK
dc.citation.issue7en_UK
dc.citation.spage3150en_UK
dc.citation.epage3162en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emaild.r.tocher@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationUniversidad Complutense de Madriden_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversidad Complutense de Madriden_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNational Agricultural Research Foundationen_UK
dc.identifier.isiWOS:000229772700034en_UK
dc.identifier.scopusid2-s2.0-22144488828en_UK
dc.identifier.wtid791966en_UK
dc.contributor.orcid0000-0002-3155-0844en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dcterms.dateAccepted2005-07-31en_UK
dc.date.filedepositdate2012-08-24en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorLeaver, Michael|0000-0002-3155-0844en_UK
local.rioxx.authorBoukouvala, Evridiki|en_UK
local.rioxx.authorAntonopoulou, Efthimia|en_UK
local.rioxx.authorDiez, Amalia|en_UK
local.rioxx.authorFavre-Krey, Laurence|en_UK
local.rioxx.authorEzaz, M Tariq|en_UK
local.rioxx.authorBautista, Jose M|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorKrey, Grigorios|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2012-08-24en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2012-08-24|en_UK
local.rioxx.filenametocher_endocrinology146_2005.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0013-7227en_UK
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