Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7620

Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Structural studies of a UDP-glucuronosyltransferase gene from the plaice (Pleuronectes platessa)
Authors: George, Stephen
Leaver, Michael
Wright, Joy
Contact Email: m.j.leaver@str.ac.uk
Issue Date: Jul-1998
Publisher: Elsevier
Citation: George S, Leaver M & Wright J (1998) Structural studies of a UDP- glucuronosyltransferase gene from the plaice (Pleuronectes platessa), Marine Environmental Research, 46 (1-5), pp. 33-35.
Abstract: A partial length cDNA coding for the putative PAH-inducible phenol-conjugating UDP-glucururonosyltransferases (UGT) isoform of plaice was used to isolate overlapping clones from a plaice genomic library. Sequence analysis revealed the presence of a complete gene spanning 4.1 kb for a plaice UGT which showed a strong conservation in exon structure, amino acid character and amino acid sequence with mammalian UGT1 family genes, although additional alternative upstream exon 1s were not identified in the present study. Southern blot analysis revealed a low copy number for the gene and some degree of structural polymorphism in gene structure between individuals. This was also reflected in the finding that there were significant variations between the nucleotide sequences of the plaice gene and the cDNA previously isolated from a different individual fish. Future studies will investigate the possibility that there may be phenotypic variations which could lead to alterations in susceptibility to pollutant toxicity.
Type: Journal Article
URI: http://hdl.handle.net/1893/7620
URL: http://www.sciencedirect.com/science/article/pii/S0141113697000536
DOI Link: http://dx.doi.org/10.1016/S0141-1136(97)00053-6
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
Aquaculture
University of Stirling

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