Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7605
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion
Authors: Tipton, Kevin
Borsheim, Elisabet
Wolf, Steven E
Sanford, Arthur P
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: muscle protein synthesis
muscle protein breakdown
stable isotopic tracers
Issue Date: Jan-2003
Publisher: The American Physiological Society
Citation: Tipton K, Borsheim E, Wolf SE, Sanford AP & Wolfe RR (2003) Acute response of net muscle protein balance reflects 24-h balance after exercise and amino acid ingestion, American Journal of Physiology - Endocrinology and Metabolism, 284 (1), pp. E76-E89.
Abstract: The purpose of this study was to determine if the acute anabolic muscle response to resistance exercise and essential amino acids (EAA) reflects the response over 24 h. Seven subjects participated in the following two 24-h studies: 1) resting (REST) and2) rest plus resistance exercise and consumption of EAA (ES). Net balance (NB) across the leg was determined for four amino acids. [13C6]phenylalanine was infused to determine mixed muscle fractional synthetic rate (FSR). Twenty-four-hour FSR was significantly greater for ES than for REST (P = 0.003). Exchange of phenylalanine across the leg was -194 ± 74 (SE) mg for ES and -371 ± 88 mg for REST (P = 0.07) over 24 h and 229 ± 42 mg (ES) and 28 ± 15 mg (REST; P less than 0.01) over 3 h corresponding to exercise and EAA consumption for ES. The difference in phenylalanine exchange between REST and ES was not different for measurements over 24 and 3 h. Increases in NB during ES were primarily the result of increases in protein synthesis. Results for other amino acids were similar. The acute anabolic response of muscle to EAA intake and exercise is additive to the response at rest and thus reflects the 24-h response.
Type: Journal Article
URI: http://hdl.handle.net/1893/7605
URL: http://ajpendo.physiology.org/content/284/1/E76.full
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas

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