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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Milk ingestion stimulates net muscle protein synthesis following resistance exercise
Authors: Elliott, Tabatha A
Cree, Melanie G
Sanford, Arthur P
Wolfe, Robert R
Tipton, Kevin
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Keywords: amino acid uptake
muscle biosies
Issue Date: Apr-2006
Publisher: American College of Sports Medicine
Citation: Elliott TA, Cree MG, Sanford AP, Wolfe RR & Tipton K (2006) Milk ingestion stimulates net muscle protein synthesis following resistance exercise, Medicine and Science in Sports and Exercise, 38 (4), pp. 667-674.
Abstract: PURPOSE: Previous studies have examined the response of muscle protein to resistance exercise and nutrient ingestion. Net muscle protein synthesis results from the combination of resistance exercise and amino acid intake. No study has examined the response of muscle protein to ingestion of protein in the context of a food. This study was designed to determine the response of net muscle protein balance following resistance exercise to ingestion of nutrients as components of milk. METHOD: Three groups of volunteers ingested one of three milk drinks each: 237 g of fat-free milk (FM), 237 g of whole milk (WM), and 393 g of fat-free milk isocaloric with the WM (IM). Milk was ingested 1 h following a leg resistance exercise routine. Net muscle protein balance was determined by measuring amino acid balance across the leg. RESULTS: Arterial concentrations of representative amino acids increased in response to milk ingestion. Threonine balance and phenylalanine balance were both greater than 0 following milk ingestion. Net amino acid uptake for threonine was 2.8-fold greater (P less than 0.05) for WM than for FM. Mean uptake of phenylalanine was 80 and 85% greater for WM and IM, respectively, than for FM, but not statistically different. Threonine uptake relative to ingested was significantly (P less than 0.05) higher for WM (21 +/- 6%) than FM (11 +/- 5%), but not IM (12 +/- 3%). Mean phenylalanine uptake/ingested also was greatest for WM, but not significantly. CONCLUSIONS: Ingestion of milk following resistance exercise results in phenylalanine and threonine uptake, representative of net muscle protein synthesis. These results suggest that whole milk may have increased utilization of available amino acids for protein synthesis.
Type: Journal Article
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Affiliation: University of Texas Medical Branch
University of Texas Medical Branch
University of Texas Medical Branch
University of Texas

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