Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7578
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Incidence of associated events during the performance of invasive procedures in healthy human volunteers
Authors: Highstead, R Grant
Tipton, Kevin
Creson, Daniel L
Wolfe, Robert R
Ferrando, Arny A
Contact Email: k.d.tipton@stir.ac.uk
Keywords: muscle biopsy
femoral catheterization
metabolic studies
subject safety
risk
Issue Date: Apr-2005
Publisher: The American Physiological Society
Citation: Highstead RG, Tipton K, Creson DL, Wolfe RR & Ferrando AA (2005) Incidence of associated events during the performance of invasive procedures in healthy human volunteers, Journal of Applied Physiology, 98 (4), pp. 1202-1206.
Abstract: Metabolic investigations often utilize arteriovenous sampling and muscle biopsy. These investigations represent some risk to the subject. We examined 369 studies performed in the General Clinical Research Center between January 1994 and May 2003 for events related to femoral catheterization and muscle biopsies. Incidents were further examined by age (younger: 18-59 yr, n = 133; and older: 60-76 yr, n = 28). There were no clinically defined major complications associated with either procedure. The incidence of femoral catheter repositioning or reinsertion was higher in the older group (25.5 vs. 9.7%). There was no difference in the incidence of premature removal of catheters, ecchymosis or hematoma, or the persistence of pain after discharge. The occurrence of all incidents did not increase with multiple catheterizations. Muscle biopsy was associated with infrequent ecchymosis or hematoma in both groups (1.1 and 3.6% in younger and older groups, respectively). Both procedures entail a small likelihood of a vagallike response (3.3% overall), resulting in nausea, dizziness, and rarely a loss of consciousness. These results indicate that, in skilled hands and a defined clinical setting, the incidents associated with femoral catheterization and muscle biopsy in healthy volunteers are reasonable and largely controllable.
Type: Journal Article
URI: http://hdl.handle.net/1893/7578
URL: http://jap.physiology.org/content/98/4/1202
DOI Link: http://dx.doi.org/10.1152/japplphysiol.01076.2004
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Texas Medical Branch
Sport
University of Texas Medical Branch
University of Texas
University of Texas

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