Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7575
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?
Authors: Bell, J Gordon
Sargent, John R
Tocher, Douglas R
Dick, James R
Contact Email: d.r.tocher@stir.ac.uk
Issue Date: Jul-2000
Publisher: Elsevier
Citation: Bell JG, Sargent JR, Tocher DR & Dick JR (2000) Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?, Prostaglandins, Leukotrienes and Essential Fatty Acids, 63 (1-2), pp. 21-25.
Abstract: The fatty acid compositions of red blood cell (RBC) phospholipids from a patient with autistic spectrum disorder (ASD) had reduced percentages of highly unsaturated fatty acids (HUFA) compared to control samples. The percentage of HUFA in the RBC from the autistic patient was dramatically reduced (up to 70%) when the sample was stored for 6 weeks at −20°C. However, only minor HUFA reductions were recorded in control samples stored similarly, or when the autistic sample was stored at −80°C. A similar instability in RBC HUFA compositions upon storage at −20°C has been recorded in schizophrenic patients. In a number of other neurodevelopmental conditions, including attention deficit hyperactivity disorder (ADHD) and dyslexia, reduced concentrations of RBC HUFA have been recorded. The extent and nature of these aberrations require further assessment to determine a possible common biochemical origin of neurodevelopmental disorders in general. To facilitate this, a large scale assessment of RBC fatty acid compositions in patients with ASD, and related disorders, should be performed as a matter of urgency. Supplementing cells in culture with the tryptophan metabolite indole acrylic acid (IAA) affected the levels of cellular HUFA and prostaglandin production. Indole acroyl glycine (IAG), a metabolite of IAA excreted in urine, is found in high concentrations in patients with neurodevelopmental disorders including ASD, ADHD, dyslexia, Asperger's syndrome and obsessive compulsive disorder.
Type: Journal Article
URI: http://hdl.handle.net/1893/7575
DOI Link: http://dx.doi.org/10.1054/plef.2000.0186
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of Stirling
Aquaculture
Aquaculture

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