|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Metformin and reduced risk of cancer in diabetic patients|
Donnelly, Louise A
Emslie-Smith, Alistair M
Alessi, Dario R
Morris, Andrew D
|Citation:||Evans J, Donnelly LA, Emslie-Smith AM, Alessi DR & Morris AD (2005) Metformin and reduced risk of cancer in diabetic patients, BMJ, 330 (7503), pp. 1304-1305.|
|Abstract:||Metformin, widely given to patients with type 2 diabetes, works by targeting the enzyme AMPK (AMP activated protein kinase), which induces muscles to take up glucose from the blood. A recent breakthrough has found the upstream regulator of AMPK to be a protein kinase known as LKB1.1 2 LKB1 is a well recognised tumour suppressor. Activation of AMPK by metformin and exercise requires LKB1, and this would also explain why exercise is beneficial in the primary and secondary prevention of certain cancers.3 We hypothesise that metformin use in patients with type 2 diabetes may reduce their risk of cancer.|
|Rights:||This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode. Published in BMJ by BMJ Publishing Group Ltd. The published article can be accessed at: http://www.bmj.com/content/330/7503/1304|
|Evans_2005_Metformin_and_reduced_risk_of_cancer.pdf||77.2 kB||Adobe PDF||View/Open|
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact firstname.lastname@example.org providing details and we will remove the Work from public display in STORRE and investigate your claim.