Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7344
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dc.contributor.authorVisscher, Kristina Men_UK
dc.contributor.authorMiezin, Francis Men_UK
dc.contributor.authorKelly, James Een_UK
dc.contributor.authorBuckner, Randyen_UK
dc.contributor.authorDonaldson, Daviden_UK
dc.contributor.authorMcAvoy, Mark Pen_UK
dc.contributor.authorBhalodia, Vidya Men_UK
dc.contributor.authorPetersen, Steve Een_UK
dc.date.accessioned2012-08-08T15:21:20Z-
dc.date.available2012-08-08T15:21:20Zen_UK
dc.date.issued2003-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/7344-
dc.description.abstractRecent functional magnetic resonance imaging (fMRI) studies using mixed blocked/event-related designs have shown activity consistent with separable sustained task-related processes and transient trial-related processes. In the mixed design, control blocks are intermixed with task blocks, during which trials are presented at varying intervals. Two studies were conducted to assess the ability of this design to detect and dissociate sustained task-related from transient trial-related activity. Analyses on both simulated and empirical data were performed by using the general linear model with a shape assumed for sustained effects, but not transient effects. In the first study, simulated data were produced with sustained time courses, transient time courses, and the sum of both together. Analyses of these data showed appropriate parsing of sustained and transient activity in all three cases. For the empirical fMRI experiment, counterphase-flickering checkerboard stimuli were constructed to produce sustained, transient, and combined sustained and transient responses in visual cortex. As with the simulation, appropriate parsing of sustained and transient activity was seen in all three cases; i.e., sustained stimuli produced sustained time courses and transient stimuli produced transient time courses. Combined stimuli produced both transient and sustained time courses. Critically, transient stimuli alone did not produce spurious positive sustained responses; sustained stimuli alone produced negligible spurious transient time courses. The results of these two studies along with supplemental simulations provide strong evidence that mixed designs are an effective tool for separating transient, trial-related activity from sustained activity in fMRI experiments. Mixed designs can allow researchers a means to examine brain activity associated with sustained processes, potentially related to task-level control signals.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationVisscher KM, Miezin FM, Kelly JE, Buckner R, Donaldson D, McAvoy MP, Bhalodia VM & Petersen SE (2003) Mixed blocked/event-related designs separate transient and sustained activity in fMRI. NeuroImage, 19 (4), pp. 1694-1708. https://doi.org/10.1016/S1053-8119%2803%2900178-2en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleMixed blocked/event-related designs separate transient and sustained activity in fMRIen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[donaldson_neuroimage_2003.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1016/S1053-8119(03)00178-2en_UK
dc.citation.jtitleNeuroImageen_UK
dc.citation.issn1053-8119en_UK
dc.citation.volume19en_UK
dc.citation.issue4en_UK
dc.citation.spage1694en_UK
dc.citation.epage1708en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emaild.i.donaldson@stir.ac.uken_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.contributor.affiliationWashington University In Saint Louisen_UK
dc.identifier.isiWOS:000185079000039en_UK
dc.identifier.scopusid2-s2.0-0041924031en_UK
dc.identifier.wtid789537en_UK
dc.contributor.orcid0000-0002-8036-3455en_UK
dcterms.dateAccepted2003-08-31en_UK
dc.date.filedepositdate2012-08-08en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorVisscher, Kristina M|en_UK
local.rioxx.authorMiezin, Francis M|en_UK
local.rioxx.authorKelly, James E|en_UK
local.rioxx.authorBuckner, Randy|en_UK
local.rioxx.authorDonaldson, David|0000-0002-8036-3455en_UK
local.rioxx.authorMcAvoy, Mark P|en_UK
local.rioxx.authorBhalodia, Vidya M|en_UK
local.rioxx.authorPetersen, Steve E|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamedonaldson_neuroimage_2003.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1053-8119en_UK
Appears in Collections:Psychology Journal Articles

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