Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7229
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum)
Authors: Nya, Elijah Jacob
Austin, Brian
Contact Email: brian.austin@stir.ac.uk
Keywords: 100
activities
Aeromonas hydrophila
BACTERIAL
challenge
Control
data
Disease
EFFICIENCY
FEED
feed conversion
fish
Growth
Health
immune
immune response
IMMUNE-RESPONSE
IMPACT
INFECTION
INFECTIONS
lysozyme
method
methods
MORTALITIES
MORTALITY
MYKISS
Oncorhynchus mykiss
ONCORHYNCHUS-MYKISS
Prevention
PROTEIN
rainbow trout
RAINBOW-TROUT
RATIO
reduction
Role
TROUT
WALBAUM
welfare
Issue Date: Feb-2010
Publisher: Blackwell Science
Citation: Nya EJ & Austin B (2010) Use of bacterial lipopolysaccharide (LPS) as an immunostimulant for the control of Aeromonas hydrophila infections in rainbow trout Oncorhynchus mykiss (Walbaum), Journal of Applied Microbiology, 108 (2), pp. 686-694.
Abstract: Aims: To determine the effect of lipopolysaccharide (LPS) for the prevention of infection by Aeromonas hydrophila in rainbow trout (Oncorhynchus mykiss Walbaum) fingerlings. Methods and Results: Rainbow trout fingerlings were fed with 0 mg (= controls), 1.875 mg, 3.75 mg, 7.5 mg and 15 mg of LPS per 100 g of commercial feed for 14 days before experimental challenge with A. hydrophila. The results revealed a reduction in mortalities to 5% in the two lowest doses and 15% in the group, which received 15 mg LPS per 100 g of feed, compared with 45% mortalities in the control. LPS exerted a powerful oxidative burst effect and was a potent mediator of phagocytic, lysozyme, bactericidal and antiprotease activities and total protein. However, whereas there were increases in specific growth rate (SGR), feed conversion ratio (FCR) and protein efficiency ratio (PER) in LPS-treated fish, the data were not significantly (P > 0.05) different. Conclusions: LPS was effective at preventing disease caused by A. hydrophila and in stimulating the innate immune response of rainbow trout.Significance and Impact of the Study: The results of this study highlight the role of LPS in fish disease control.
Type: Journal Article
URI: http://hdl.handle.net/1893/7229
DOI Link: http://dx.doi.org/10.1111/j.1365-2672.2009.04464.x
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Heriot-Watt University
Aquaculture

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