Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/7172
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Two-Phase Resolution of Polyploidy in the Arabidopsis Metabolic Network Gives Rise to Relative and Absolute Dosage Constraints
Authors: Bekaert, Michaël
Edger, Patrick P
Pires, J Chris
Conant, Gavin C
Contact Email: michael.bekaert@stir.ac.uk
Issue Date: May-2011
Publisher: American Society of Plant Biologists
Citation: Bekaert M, Edger PP, Pires JC & Conant GC (2011) Two-Phase Resolution of Polyploidy in the Arabidopsis Metabolic Network Gives Rise to Relative and Absolute Dosage Constraints, Plant Cell, 23 (5), pp. 1719-1728.
Abstract: The abundance of detected ancient polyploids in extant genomes raises questions regarding evolution after whole-genome duplication (WGD). For instance, what rules govern the preservation or loss of the duplicated genes created by WGD? We explore this question by contrasting two possible preservation forces: selection on relative and absolute gene dosages. Constraints on the relative dosages of central network genes represent an important force for maintaining duplicates (the dosage balance hypothesis). However, preservation may also result from selection on the absolute abundance of certain gene products. The metabolic network of the model plant Arabidopsis thaliana is a powerful system for comparing these hypotheses. We analyzed the surviving WGD-produced duplicate genes in this network, finding evidence that the surviving duplicates from the most recent WGD (WGD-α) are clustered in the network, as predicted by the dosage balance hypothesis. A flux balance analysis suggests an association between the survival of duplicates from a more ancient WGD (WGD-β) and reactions with high metabolic flux. We argue for an interplay of relative and absolute dosage constraints, such that the relative constraints imposed by the recent WGD are still being resolved by evolution, while they have been essentially fully resolved for the ancient event.
Type: Journal Article
URI: http://hdl.handle.net/1893/7172
DOI Link: http://dx.doi.org/10.1105/tpc.110.081281
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Aquaculture
University of Missouri - Columbia
University of Missouri - Columbia
University of Missouri - Columbia
University of Missouri - Columbia
University of Missouri - Columbia
University of Missouri - Columbia

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