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http://hdl.handle.net/1893/37910| Appears in Collections: | History and Politics Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Plague and Yersinia pestis: Some Knowns and Unknowns |
| Author(s): | Yang, Ruifu Atkinson, Steve Chen, Zigi Cui, Yujun Du, Zongmin Han, Yanping Sebbane, Florent Slavin, Philip Song, Yajun Yan, Yanfeng Wu, Yarong Xu, Lei Zhang, Chutian Zhang, Yun Hinnebusch, Joseph |
| Contact Email: | philip.slavin@stir.ac.uk |
| Keywords: | diagnostic vaccine evolution physiology bioterrorism plague Yersinia pestis immunity treatment pathogenesis |
| Issue Date: | 19-Jan-2023 |
| Date Deposited: | 4-Feb-2026 |
| Citation: | Yang R, Atkinson S, Chen Z, Cui Y, Du Z, Han Y, Sebbane F, Slavin P, Song Y, Yan Y, Wu Y, Xu L, Zhang C, Zhang Y & Hinnebusch J (2023) Plague and Yersinia pestis: Some Knowns and Unknowns. <i>Zoonoses</i>, 3 (1), Art. No.: e995. https://doi.org/10.15212/ZOONOSES-2022-0040 |
| Abstract: | Since its first identification in 1894 during the third pandemic in Hong Kong, there has been significant progress in understanding the lifestyle of Yersinia pestis, the pathogen that is responsible for plague. Although we now have some understanding of the pathogen’s physiology, genetics, genomics, evolution, gene regulation, pathogenesis and immunity, there are many unknown aspects of the pathogen and its disease development. Here, we focus on some of the knowns and unknowns related to Y. pestis and plague. We notably focus on some key Y. pestis physiologic and virulence traits that are important for its mammal-flea-mammal life cycle, but also its emergence from the enteropathogen, Yersinia pseudotuberculosis. Some aspects of the genetic diversity of Y. pestis, the distribution and ecology of plague, as well as the medical countermeasures to protect our population are also provided. Lastly, we present some biosafety and biosecurity information related to Y. pestis and plague. |
| DOI Link: | 10.15212/ZOONOSES-2022-0040 |
| Rights: | This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY) 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited. |
| Notes: | Additional authors: Nils Chr. Stenseth, Vladimir L. Motin |
| Licence URL(s): | http://creativecommons.org/licenses/by/4.0/ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Yang et al._ 2023_ Yersinia Pestis and Plague. Some Knowns and Unknowns.pdf | Fulltext - Published Version | 1.72 MB | Adobe PDF | View/Open |
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