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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/34428
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dc.contributor.authorTschesche, Claudiaen_UK
dc.contributor.authorBekaert, Michaëlen_UK
dc.contributor.authorBassett, David Ien_UK
dc.contributor.authorBoyd, Sallyen_UK
dc.contributor.authorBron, James Een_UK
dc.contributor.authorSturm, Arminen_UK
dc.date.accessioned2022-06-22T00:02:48Z-
dc.date.available2022-06-22T00:02:48Z-
dc.date.issued2022en_UK
dc.identifier.other10356en_UK
dc.identifier.urihttp://hdl.handle.net/1893/34428-
dc.description.abstractThe pyrethroid deltamethrin (DTM) is used to treat Atlantic salmon (Salmo salar) against salmon louse (Lepeophtheirus salmonis) infestations. However, DTM resistance has evolved in L. salmonis and is currently common in the North Atlantic. This study aimed to re-assess the association between DTM resistance and mitochondrial (mtDNA) mutations demonstrated in previous reports. Among 218 L. salmonis collected in Scotland in 2018–2019, 89.4% showed DTM resistance in bioassays, while 93.6% expressed at least one of four mtDNA single nucleotide polymorphisms (SNPs) previously shown to be resistance associated. Genotyping at further 14 SNP loci allowed to define three resistance-associated mtDNA haplotypes, named 2, 3 and 4, occurring in 72.0%, 14.2% and 7.3% of samples, respectively. L. salmonis strains IoA-02 (haplotype 2) and IoA-10 (haplotype 3) both showed high levels (~ 100-fold) of DTM resistance, which was inherited maternally in crossing experiments. MtDNA haplotypes 2 and 3 differed in genotype for 17 of 18 studied SNPs, but shared one mutation that causes an amino acid change (Leu107Ser) in the cytochrome c oxidase subunit 1 (COX1) and was present in all DTM resistant while lacking in all susceptible parasites. We conclude that Leu107Ser (COX1) is a main genetic determinant of DTM resistance in L. salmonis.en_UK
dc.language.isoenen_UK
dc.publisherSpringer Science and Business Media LLCen_UK
dc.relationTschesche C, Bekaert M, Bassett DI, Boyd S, Bron JE & Sturm A (2022) Key role of mitochondrial mutation Leu107Ser (COX1) in deltamethrin resistance in salmon lice (Lepeophtheirus salmonis). Scientific Reports, 12 (1), Art. No.: 10356. https://doi.org/10.1038/s41598-022-14023-1en_UK
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectEvolutionen_UK
dc.subjectGeneticsen_UK
dc.subjectOcean sciencesen_UK
dc.titleKey role of mitochondrial mutation Leu107Ser (COX1) in deltamethrin resistance in salmon lice (Lepeophtheirus salmonis)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1038/s41598-022-14023-1en_UK
dc.identifier.pmid35725748en_UK
dc.citation.jtitleScientific Reportsen_UK
dc.citation.issn2045-2322en_UK
dc.citation.volume12en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBBSRC Biotechnology and Biological Sciences Research Councilen_UK
dc.contributor.funderMarine Alliance for Science & Technology Scotlanden_UK
dc.contributor.funderPHARMAQ/Zoetisen_UK
dc.citation.date20/06/2022en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationMachrihanishen_UK
dc.contributor.affiliationMachrihanishen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.wtid1823511en_UK
dc.contributor.orcid0000-0002-1206-7654en_UK
dc.contributor.orcid0000-0002-7529-0829en_UK
dc.contributor.orcid0000-0003-3544-0519en_UK
dc.contributor.orcid0000-0003-2632-1999en_UK
dc.date.accepted2022-03-30en_UK
dcterms.dateAccepted2022-03-30en_UK
dc.date.filedepositdate2022-06-21en_UK
dc.relation.funderprojectIdentifying molecular determinants of drug susceptibility in salmon lice (Lepeophtheirus salmonis)en_UK
dc.relation.funderrefBB/L022923/1en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorTschesche, Claudia|en_UK
local.rioxx.authorBekaert, Michaël|0000-0002-1206-7654en_UK
local.rioxx.authorBassett, David I|0000-0002-7529-0829en_UK
local.rioxx.authorBoyd, Sally|en_UK
local.rioxx.authorBron, James E|0000-0003-3544-0519en_UK
local.rioxx.authorSturm, Armin|0000-0003-2632-1999en_UK
local.rioxx.projectBB/L022923/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2022-06-21en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2022-06-21|en_UK
local.rioxx.filenames41598-022-14023-1.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2045-2322en_UK
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