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http://hdl.handle.net/1893/34151| Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Safety and efficacy of e-cigarettes versus nicotine patches when used to help pregnant smokers quit. A randomised controlled trial |
| Author(s): | Hajek, Peter Przulj, Dunja Pesola, Francesca Griffiths, Christopher Walton, Robert McRobbie, Hayden Coleman, Tim Lewis, Sarah Whitemore, Rachel Clark, Miranda Ussher, Michael Sinclair, Lesley Seager, Emilie Cooper, Sue Bauld, Linda Naughton, Felix Saseni, Peter Manyonda, Isaac Myers Smith, Katie |
| Contact Email: | aileen.paton@stir.ac.uk |
| Date Deposited: | 11-Apr-2022 |
| Citation: | Hajek P, Przulj D, Pesola F, Griffiths C, Walton R, McRobbie H, Coleman T, Lewis S, Whitemore R, Clark M, Ussher M, Sinclair L, Seager E, Cooper S, Bauld L, Naughton F, Saseni P, Manyonda I & Myers Smith K (2022) Safety and efficacy of e-cigarettes versus nicotine patches when used to help pregnant smokers quit. A randomised controlled trial. <i>Nature Medicine</i>. |
| Abstract: | Nicotine replacement therapy is commonly offered to pregnant women who smoke to help them quit, but it has limited efficacy in this group. E-cigarettes are also used by pregnant smokers, but their safety and efficacy in pregnancy are unknown. Here we report the results of comparing nicotine patches with refillable e-cigarettes in a randomised controlled trial involving 1,140 participants. In the unadjusted primary analysis, validated prolonged quit rates at the end of pregnancy in the two study arms were not significantly different, but some abstainers in the patch arm used e-cigarettes. In a pre-specified sensitivity analysis excluding abstainers using non-allocated products, e-cigarettes were markedly more effective than patches.Low birthweight ( |
| Rights: | This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. |
| Notes: | Output Status: Forthcoming |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Hajek_2022-Nature Medicine (1).pdf | Fulltext - Accepted Version | 1.1 MB | Adobe PDF | View/Open |
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