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http://hdl.handle.net/1893/32253| Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Relationship between cytokines and symptoms in people with incurable cancer: A systematic review |
| Author(s): | Patton, Rebekah Paval, D Robert McDonald, James J Brown, Duncan Gallagher, Iain J Skipworth, Richard J E McMillan, Donald C Dolan, Ross D Fallon, Marie Laird, Barry J A |
| Contact Email: | i.j.gallagher@stir.ac.uk |
| Keywords: | Cytokines Palliative medicine Symptoms Systemic inflammatory response Cancer |
| Issue Date: | Mar-2021 |
| Date Deposited: | 8-Feb-2021 |
| Citation: | Patton R, Paval DR, McDonald JJ, Brown D, Gallagher IJ, Skipworth RJE, McMillan DC, Dolan RD, Fallon M & Laird BJA (2021) Relationship between cytokines and symptoms in people with incurable cancer: A systematic review. Critical Reviews in Oncology/Hematology, 159, Art. No.: 103222. https://doi.org/10.1016/j.critrevonc.2021.103222 |
| Abstract: | Background Development and spread of cancer is linked to the inflammatory response, in which cytokines serve a key role. The inflammatory response may also form the basis for symptoms of cancer. This systematic review examines the relationship between cytokines and symptoms in incurable cancer. Methods MEDLINE, EMBASE, Cochrane Library, CINAHL, Web of Science and PsycINFO databases were searched for studies from January 2004 to January 2020. Results Twenty studies were selected (n = 1806 patients, 119 controls). Symptoms studied included depression, fatigue, pain, and loss of appetite. Nine studies examined patients with a specified tumour type, the remainder included patients with a mix of tumour types. Thirty-one cytokines were examined; multiple associations between cytokines and symptoms were described, supporting the hypothesis that cytokines may have a key role in symptom generation. Conclusion Symptoms of incurable cancer are associated with circulating cytokines. Further study is required to characterise these relationships, and to explore their therapeutic potential. |
| DOI Link: | 10.1016/j.critrevonc.2021.103222 |
| Rights: | This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Patton R, Paval DR, McDonald JJ, Brown D, Gallagher IJ, Skipworth RJE, McMillan DC, Dolan RD, Fallon M & Laird BJA (2021) Relationship between cytokines and symptoms in people with incurable cancer: A systematic review. Critical Reviews in Oncology/Hematology, 159, Art. No.: 103222. https://doi.org/10.1016/j.critrevonc.2021.103222 © 2021, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Licence URL(s): | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| Patton-etal-CROH-2021.pdf | Fulltext - Accepted Version | 485.82 kB | Adobe PDF | View/Open |
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