Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/3219
Appears in Collections:Psychology Book Chapters and Sections
Title: Mild cognitive impairment - a five year follow-up and imaging study
Authors: Lonie, Jane A
Kalu, Ukwuori G
Sexton, Claire E
Mackay, Clare E
Bastin, Mark E
Terriere, Emma
O'Carroll, Ronan
Ebmeier, Klaus P
Contact Email: ronan.ocarroll@stir.ac.uk
Editors: Palomo, Tomas
Kostzewa, Richard M
Beninger, Richard J
Citation: Lonie JA, Kalu UG, Sexton CE, Mackay CE, Bastin ME, Terriere E, O'Carroll R & Ebmeier KP (2011) Mild cognitive impairment - a five year follow-up and imaging study. In: Palomo Tomas, Kostzewa Richard M, Beninger Richard J (ed.). Staging Neuropsychiatric Disorders. Current Topics in Neurotoxicity, Vol. 5, 10, Madrid: Springer, pp. 183-194.
Keywords: Mild cognitive impairment
Alzheimer’s disea
follow-up study
neuropsychology
single photon emission tomography
diffusion tensor magnetic resonance imaging
Issue Date: 2011
Publisher: Springer
Series/Report no.: Current Topics in Neurotoxicity, Vol. 5, 10
Abstract: Forty-six patients with mild cognitive impairment (MCI), twenty patients with very early Alzheimer’s disease (AD), twenty psychiatric outpatients with depressive symptoms, and 24 health elderly volunteers were examined cross- sectionally using clinical and neuropsychological scales. Patients with amnestic mild cognitive impairment were followed up on average for four years. Smaller subgroups of patients were examined with an α4β2-nicotinic ligand tracer and single photon emission tomography, and diffusion tensor magnetic resonance imaging to examine white matter tract micro-integrity. One quarter of referrals to our Edinburgh neuropsychological assessment service for older people received the diagnosis of amnestic mild cognitive impairment (aMCI). Most of these also displayed non-memory cognitive deficits, without qualifying for a diagnosis of dementia. While some of the neuropsychological measures were highly specific and sensitive to early dementia, they achieved usually only one of the two for aMCI. Two fifths or our aMCI patients ‘converted’ to AD within four years of follow- up. They could be predicted at baseline with an accuracy of 75%. Typical patterns of nicotinic receptor binding and white matter integrity were found in patients w
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Type: Part of book or chapter of book
URI: http://hdl.handle.net/1893/3219
URL: http://www.springer.com/biomed/neuroscience/book/978-1-4614-0784-3
Affiliation: Royal Edinburgh Hospital
University of Oxford
University of Oxford
University of Oxford
University of Edinburgh
University of Edinburgh
Psychology
University of Edinburgh

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