Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/3144
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Essential Amino Acids for Muscle Protein Accretion
Authors: Ferrando, Arny A
Tipton, Kevin
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: essential amino acids
muscle protein synthesis
Issue Date: Feb-2010
Publisher: Lippincott William & Wilkins / National Strength and Conditioning Association
Citation: Ferrando AA, Tipton K & Wolfe RR (2010) Essential Amino Acids for Muscle Protein Accretion, Strength and Conditioning Journal, 32 (1), pp. 87-92.
Abstract: SUMMARY: THE STIMULATION OF MUSCLE PROTEIN SYNTHESIS IS RELIANT ON THE ADEQUATE AVAILABILITY OF AMINO ACID (AA) PRECURSORS. THE INCREASE IN CIRCULATING AA CONCENTRATIONS IN THE BLOOD SERVES AS A SIGNAL TO INITIATE SYNTHETIC PROCESSES. A SUFFICIENT INCREASE IN BLOOD AA IS REQUIRED TO OVERCOME A CONCENTRATION GRADIENT THAT NORMALLY FAVORS THE INTRACELLULAR SPACE. WE HAVE DEMONSTRATED THAT THE RATE OF MUSCLE PROTEIN SYNTHESIS IS DIRECTLY RELATED TO THE RATE OF APPEARANCE OF AA IN THE INTRACELLULAR SPACE. MUSCLE PROTEINS COMPRISE VARIOUS ESSENTIAL AND NONESSENTIAL AA; HOWEVER, ONLY INGESTION OF THE ESSENTIAL AMINO ACIDS (EAA) IS REQUIRED TO STIMULATE MUSCLE PROTEIN SYNTHESIS. WHILE EAA ALONE STIMULATE MUSCLE PROTEIN ANABOLISM, THE EFFECT IS MAGNIFIED WHEN COMBINED WITH EXERCISE. FURTHERMORE, THE TIMING OF INGESTION IN RELATION TO EXERCISE IS IMPORTANT IN ACHIEVING A MAXIMAL ANABOLIC RESPONSE. THE BENEFITS OF FREE-FORM EAA AND INTACT PROTEIN ON EXERCISE-INDUCED MUSCLE ANABOLISM ARE DISCUSSED. FINALLY, THE EFFECTS OF AGING MUST BE CONSIDERED IN THE OPTIMAL EAA FORMULATION.
Type: Journal Article
URI: http://hdl.handle.net/1893/3144
DOI Link: http://dx.doi.org/10.1519/SSC.0b013e3181c212a3
Rights: Copyright National Strength and Conditioning Association. Copyright Lippincott Williams and Wilkins.; The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Affiliation: University of Arkansas for Medical Sciences
Sport
University of Arkansas for Medical Sciences

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