Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/3094
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein
Authors: Tipton, Kevin
Elliott, Tabatha A
Ferrando, Arny A
Aarsland, Asle A
Wolfe, Robert R
Contact Email: k.d.tipton@stir.ac.uk
Keywords: arteriovenous balance
net muscle protein synthesis
Issue Date: Apr-2009
Publisher: NRC Research Press / Canadian Science Publishing
Citation: Tipton K, Elliott TA, Ferrando AA, Aarsland AA & Wolfe RR (2009) Stimulation of muscle anabolism by resistance exercise and ingestion of leucine plus protein, Applied Physiology, Nutrition, and Metabolism, 34 (2), pp. 151-161.
Abstract: Leucine is known to stimulate muscle protein synthesis and anabolism. However, evidence for the efficacy of additional leucine to enhance the response of muscle anabolism to resistance exercise and protein ingestion is unclear. Thus, we investigated the response of net muscle protein balance to ingestion of additional leucine with protein in association with resistance exercise. Two groups of untrained subjects performed an intense bout of leg resistance exercise following ingestion of 1 of 2 drinks: flavored water (PL); or 16.6 g of whey protein + 3.4 g of leucine (W+L). Arteriovenous amino acid balance across the leg was measured to assess the anabolic response of muscle in each group. Arterial amino acid concentrations increased in response to ingestion of W+L. Amino acid concentrations peaked between 60 and 120 min after ingestion, and then declined to baseline values. Valine concentration decreased to levels significantly lower than baseline. Net balance of leucine, threonine, and phenylalanine did not change following PL ingestion, but increased and remained elevated above baseline for 90–120 min following W+L ingestion. Leucine (138 ± 37 and –23 ± 23 mg), phenylalanine (58 ± 28 and –38 ± 14 mg), and threonine (138 ± 37 and –23 ± 23 mg) uptake was greater for W+L than for PL over the 5.5 h following drink ingestion. Our results indicate that the whey protein plus leucine in healthy young volunteers results in an anabolic response in muscle that is not greater than the previously reported response to whey protein alone.
Type: Journal Article
URI: http://hdl.handle.net/1893/3094
DOI Link: http://dx.doi.org/10.1139/H09-006
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Affiliation: Sport
University of Texas Medical Branch
University of Texas
University of Texas Medical Branch
University of Texas

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