Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2917
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dc.contributor.authorJordal, Ann-Elise Oen_UK
dc.contributor.authorTorstensen, Bente Een_UK
dc.contributor.authorTsoi, Stephenen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorLall, Santosh Pen_UK
dc.contributor.authorDouglas, Susan Een_UK
dc.date.accessioned2012-09-03T12:20:48Z-
dc.date.available2012-09-03T12:20:48Zen_UK
dc.date.issued2005-10en_UK
dc.identifier.urihttp://hdl.handle.net/1893/2917-
dc.description.abstractSupplies of marine fish oils (FO ) are limited, and sustainable production in aquaculture dictates that alternatives, such as vegetable oils, must be found that do not compromise fish health and product quality. Nutrigenomics is anticipated to provide an increased understanding of how nutrition influences metabolic pathways and homeostatic control, and may be used to measure and validate subtle changes in organ-specific, metabolic gene expression signatures. We have compared two groups of Atlantic salmon fed diets containing 100% FO or 75% rapeseed oil (RO)/25% FO for 42 weeks. A small-scale cDNA microarray was constructed to screen for changes in expression of lipid metabolism genes in the liver resulting from this partial substitution of RO for FO. Fatty acid desaturase gene expression was significantly increased in fish fed 75% RO compared to fish fed the control diet; this was confirmed by quantitative Real Time PCR analysis (Q-PCR). In addition, several genes, among these mitochondrial proteins, peroxisome proliferator activated receptor-γ (PPARγ) as well as other transcription factors, co-activators and signal transducers, showed significant differential regulation. This partially validated microarray may be used for further gene expression profiling using other dietary comparisons.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Society for Nutritional Sciencesen_UK
dc.relationJordal AO, Torstensen BE, Tsoi S, Tocher DR, Lall SP & Douglas SE (2005) Dietary rapeseed oil affects the expression of genes involved in hepatic lipid metabolism in Atlantic salmon (Salmo salar L.). Journal of Nutrition, 135 (10), pp. 2355-2361. http://jn.nutrition.org/content/135/10/2355.abstracten_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAtlantic salmonen_UK
dc.subjectSalmo salaren_UK
dc.subjectfish olen_UK
dc.subjectvegetable oilen_UK
dc.subjectgene expressionen_UK
dc.subjectmicroarrayen_UK
dc.subjectQPCRen_UK
dc.subjectLipid metabolismen_UK
dc.subjectAtlantic salmonen_UK
dc.subjectFishes Feeding and feedsen_UK
dc.subjectFishes Nutritionen_UK
dc.subjectDietary supplementsen_UK
dc.subjectFishes Qualityen_UK
dc.titleDietary rapeseed oil affects the expression of genes involved in hepatic lipid metabolism in Atlantic salmon (Salmo salar L.)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Jordal final.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleJournal of Nutritionen_UK
dc.citation.issn1541-6100en_UK
dc.citation.issn0022-3166en_UK
dc.citation.volume135en_UK
dc.citation.issue10en_UK
dc.citation.spage2355en_UK
dc.citation.epage2361en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.identifier.urlhttp://jn.nutrition.org/content/135/10/2355.abstracten_UK
dc.author.emaildrt1@stir.ac.uken_UK
dc.citation.date31/10/2005en_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.identifier.scopusid2-s2.0-26444552886en_UK
dc.identifier.wtid836979en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dcterms.dateAccepted2005-10-31en_UK
dc.date.filedepositdate2011-04-14en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorJordal, Ann-Elise O|en_UK
local.rioxx.authorTorstensen, Bente E|en_UK
local.rioxx.authorTsoi, Stephen|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorLall, Santosh P|en_UK
local.rioxx.authorDouglas, Susan E|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameJordal final.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0022-3166en_UK
Appears in Collections:Aquaculture Journal Articles

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