Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2901
Appears in Collections:Psychology Book Chapters and Sections
Title: Glutamate Signalling in the Skin
Authors: Cahusac, Peter
Contact Email: p.m.b.cahusac@stir.ac.uk
Editors: Paley, Benjamin F
Warfield, Tomas E
Citation: Cahusac P (2008) Glutamate Signalling in the Skin. In: Paley Benjamin F, Warfield Tomas E (ed.). Amino Acid Receptor Research, New York: Nova Science Publishers, pp. 119-131.
Issue Date: 2008
Publisher: Nova Science Publishers
Abstract: Many cellular elements of the skin appear to involve glutamate for signalling. This has been most extensively studied in nociceptive nerve endings (supplied by C and Aδ fibres). Both ionotropic and metabotropic glutamate receptors are involved in inflammation, and modulate hyperalgesia and allodynia. Less work has been on low threshold mechanoreceptors in the skin (supplied by Aβ fibres), although there is clear evidence for a modulatory role here too. There is evidence that other structural cellular elements, such as keratinocytes use glutamate for signaling, and may be important for skin growth and wound healing. Finally, excessive release of glutamate and/or aberrant expression of metabotropic glutamate receptors may be contributory factors in the development of skin melanomas. There appears to be significant clinical potential in the development of topically applied glutamate receptor active compounds to treat a range of different skin disorder
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.
Type: Part of book or chapter of book
URI: http://hdl.handle.net/1893/2901
URL: https://www.novapublishers.com/catalog/product_info.php?products_id=6810
Affiliation: Psychology

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