Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/28179
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Bodybuilders' Body Composition: Effect of Nandrolone Decanoate
Author(s): Van Marken Lichtenbelt, Wouter D
Hartgens, Fred
Vollaard, Niels
Ebbing, Spike
Kuipers, Harm
Contact Email: n.vollaard@stir.ac.uk
Keywords: Four-component model
Dexa
Deuterium dilution
Underwater weighing
Extracellular water
Intracellular water
Issue Date: 31-Mar-2004
Date Deposited: 6-Nov-2018
Citation: Van Marken Lichtenbelt WD, Hartgens F, Vollaard N, Ebbing S & Kuipers H (2004) Bodybuilders' Body Composition: Effect of Nandrolone Decanoate. Medicine and Science in Sports and Exercise, 36 (3), pp. 484-489. https://doi.org/10.1249/01.MSS.0000117157.06455.B0
Abstract: Introduction: The use of androgenic-anabolic steroids (AAS) among bodybuilders to increase muscle mass is widespread. Nandrolone decanoate (ND) is one of the most popular misused AAS, although the effects on body composition are equivocal. Therefore, the purpose of this study was to determine the effect of ND on body composition in male bodybuilders, with special reference to muscle mass alterations. Methods: Using a randomized "double-blind" "placebo-controlled" design, 16 experienced male bodybuilders (age: 19-44 yr) either received ND (200 mg·wk-1, intramuscularly) or placebo for 8 wk. Body composition was assessed using the four-component model, combining results from underwater weighing, dual-energy x-ray absorptiometry (DXA), and deuterium dilution. Total bone mineral content and density were measured using DXA. Water compartments (extracellular water [ECW] and intracellular water [ICW]) were determined using deuterium dilution and bromide dilution. Results: ND administration resulted in significant increments of body mass (+2.2 kg), fat-free mass (FFM: +2.6 kg), and total body water (+1.4 kg). No significant changes in fat mass, percentage fat, ECW, ICW, ECW/ICW ratio, hydration of the FFM, and on bone mineral measurements were observed. Conclusions: The results show that the administration of 200 mg·wk-1 of ND (intramuscularly) for 8 wk significantly increased body mass and FFM, whereas fat mass, bone mineral content, bone mineral density, and the hydration of the FFM remained unaffected. These data indicate that the changes can be attributed to an increase of muscle mass.
DOI Link: 10.1249/01.MSS.0000117157.06455.B0
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