Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25847
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dc.contributor.authorHarland, Bruceen_UK
dc.contributor.authorGrieves, Rodericken_UK
dc.contributor.authorBett, Daviden_UK
dc.contributor.authorStentiford, Rachaelen_UK
dc.contributor.authorWood, Emma Ren_UK
dc.contributor.authorDudchenko, Paulen_UK
dc.date.accessioned2017-10-02T22:56:12Z-
dc.date.available2017-10-02T22:56:12Z-
dc.date.issued2017-09-11en_UK
dc.identifier.urihttp://hdl.handle.net/1893/25847-
dc.description.abstractA central tenet of systems neuroscience is that the mammalian hippocampus provides a cognitive map of the environment. This view is supported by the finding of place cells, neurons whose firing is tuned to specific locations in an animal’s environment, within this brain region. Recent work, however, has shown that these cells repeat their firing fields across visually identical maze compartments [1,2]. This repetition is not observed if these compartments face different directions, suggesting that place cells use a directional input to differentiate otherwise similar local environments [3,4]. A clear candidate for this input is the head direction cell system. To test this, we disrupted the head direction cell system by lesioning the lateral mammillary nuclei, and then recorded place cells as rats explored multiple, connected compartments, oriented in the same or in different directions. As shown previously, we found that place cells in control animals exhibited repeated fields in compartments arranged in parallel, but not in compartments facing different directions. In contrast, the place cells of animals with lesions of the head direction cell system exhibited repeating fields in both conditions. Thus, directional information provided by the head direction cell system appears essential for the angular disambiguation by place cells of visually identical compartments.en_UK
dc.language.isoenen_UK
dc.publisherCell Pressen_UK
dc.relationHarland B, Grieves R, Bett D, Stentiford R, Wood ER & Dudchenko P (2017) Lesions of the head direction cell system increase hippocampal place field repetition. Current Biology, 27 (11), pp. 2706-2712.e2. https://doi.org/10.1016/j.cub.2017.07.071en_UK
dc.relation.urihttp://hdl.handle.net/11667/99en_UK
dc.rightsThis is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectplace cellsen_UK
dc.subjecthippocampusen_UK
dc.subjecthead direction cellsen_UK
dc.subjectnavigationen_UK
dc.titleLesions of the head direction cell system increase hippocampal place field repetitionen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.cub.2017.07.071en_UK
dc.identifier.pmid28867207en_UK
dc.citation.jtitleCurrent Biologyen_UK
dc.citation.issn1879-0445en_UK
dc.citation.issn0960-9822en_UK
dc.citation.volume27en_UK
dc.citation.issue11en_UK
dc.citation.spage2706en_UK
dc.citation.epage2712.e2en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.author.emailp.a.dudchenko@stir.ac.uken_UK
dc.citation.date31/08/2017en_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationPsychologyen_UK
dc.identifier.isiWOS:000410175200050en_UK
dc.identifier.scopusid2-s2.0-85028516011en_UK
dc.identifier.wtid522087en_UK
dc.contributor.orcid0000-0002-1531-5713en_UK
dc.date.accepted2017-07-31en_UK
dcterms.dateAccepted2017-07-31en_UK
dc.date.filedepositdate2017-08-08en_UK
dc.relation.funderprojectLandmark processing in the mammalian brain: do head direction cells drive grid cells and spatial behaviour?en_UK
dc.relation.funderrefBB/L000040/1en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorHarland, Bruce|en_UK
local.rioxx.authorGrieves, Roderick|en_UK
local.rioxx.authorBett, David|en_UK
local.rioxx.authorStentiford, Rachael|en_UK
local.rioxx.authorWood, Emma R|en_UK
local.rioxx.authorDudchenko, Paul|0000-0002-1531-5713en_UK
local.rioxx.projectBB/L000040/1|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2017-09-08en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2017-09-08|en_UK
local.rioxx.filename1-s2.0-S0960982217310096-main.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0960-9822en_UK
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