|Appears in Collections:||Computing Science and Mathematics Conference Papers and Proceedings|
|Peer Review Status:||Refereed|
|Title:||Process Algebra with Layers: Multi-scale Integration Modelling applied to Cancer Therapy|
|Citation:||Scott E, Nicol J, Coulter J, Hoyle A & Shankland C (2017) Process Algebra with Layers: Multi-scale Integration Modelling applied to Cancer Therapy In: Bracciali A, Caravagna G, Gilbert D, Tagliaferri R (ed.) Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2016, Cham, Switzerland: Springer. CIBB2016: 13th International Conference on Computational Intelligence methods for Bioinformatics and Biostatistics, 1.9.2016 - 3.9.2016, Stirling, UK, pp. 118-133.|
|Series/Report no.:||Lecture Notes in Computer Science, 10477|
|Conference Name:||CIBB2016: 13th International Conference on Computational Intelligence methods for Bioinformatics and Biostatistics|
|Conference Location:||Stirling, UK|
|Abstract:||We present a novel Process Algebra designed for multi-scale integration modelling: Process Algebra with Layers (PAL). The unique feature of PAL is the modularisation of scale into integrated layers: Object and Population. An Object can represent a molecule, organelle, cell, tissue, organ or any organism. Populations hold specific types of Object, for example, life stages, cell phases and infectious states. The syntax and semantics of this novel language are presented. A PAL model of the multi-scale system of cell growth and damage from cancer treatment is given. This model allows the analysis of different scales of the system. The Object and Population levels give insight into the length of a cell cycle and cell population growth respectively. The PAL model results are compared to wet laboratory survival fractions of cells given different doses of radiation treatment . This comparison shows how PAL can be used to aid in investigations of cancer treatment in systems biology.|
|Status:||Book Chapter: author post-print (pre-copy editing)|
|Rights:||Publisher policy allows this work to be made available in this repository. Published In: Bracciali A., Caravagna G., Gilbert D., Tagliaferri R. (eds) Computational Intelligence Methods for Bioinformatics and Biostatistics. CIBB 2016. Lecture Notes in Computer Science, vol 10477. Springer, Cham. The final publication is available at Springer via https://doi.org/10.1007/978-3-319-67834-4_10|
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