Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25432
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults
Authors: Jackson, Philippa A
Forster, Joanne S
Bell, J Gordon
Dick, James R
Younger, Irene
Kennedy, David O
Keywords: DHA
EPA
omega-3 polyunsaturated fatty acids
NIRS
cerebral blood flow
cognitive decline
Issue Date: 9-Feb-2016
Citation: Jackson PA, Forster JS, Bell JG, Dick JR, Younger I & Kennedy DO (2016) DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults, Nutrients, 8 (2), Art. No.: 86.
Abstract: A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids ( n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B9 and B12) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50–70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial. Relative changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin were assessed using Near Infrared Spectroscopy (NIRS) during the performance of cognitive tasks prior to and following the intervention period. Performance on the cognitive tasks was also assessed. No effect of either active treatment was found for any of the NIRS measures or on the cognitive performance tasks, although the study was limited by a number of factors. Further work should continue to evaluate more holistic approaches to cognitive aging.
DOI Link: http://dx.doi.org/10.3390/nu8020086
Rights: © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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