Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24873
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial
Authors: Da, Boit Mariasole
Sibson, Rachael
Sivasubramaniam, Selvaraj
Meakin, Judith R
Greig, Carolyn A
Aspden, Richard M
Thies, Frank
Jeromson, Stewart
Hamilton, David Lee
Speakman, John R
Hambly, Catherine
Mangoni, Arduino A
Preston, Thomas
Gray, Stuart R
Contact Email: d.l.hamilton@stir.ac.uk
Keywords: aging
exercise
fatty acids
muscle
sarcopenia
Issue Date: Jan-2017
Citation: Da Boit M, Sibson R, Sivasubramaniam S, Meakin JR, Greig CA, Aspden RM, Thies F, Jeromson S, Hamilton DL, Speakman JR, Hambly C, Mangoni AA, Preston T & Gray SR (2017) Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial, American Journal of Clinical Nutrition, 105 (1), pp. 151-158.
Abstract: Background: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n–3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men.  Objective: We sought to determine the effects of long-chain n–3 PUFA supplementation on resistance exercise training–induced increases in muscle mass and function and whether these effects differ between older men and women.  Design: Fifty men and women [men:n= 27, mean ± SD age: 70.6 ± 4.5 y, mean ± SD body mass index (BMI; in kg/m2): 25.6 ± 4.2; women:n= 23, mean ± SD age: 70.7 ± 3.3 y, mean ± SD BMI: 25.3 ± 4.7] were randomly assigned to either long-chain n–3 PUFA (n= 23; 3 g fish oil/d) or placebo (n= 27; 3 g safflower oil/d) and participated in lower-limb resistance exercise training twice weekly for 18 wk. Muscle size, strength, and quality (strength per unit muscle area), functional abilities, and circulating metabolic and inflammatory markers were measured before and after the intervention.  Results: Maximal isometric torque increased after exercise training to a greater (P <0.05) extent in the long-chain n–3 PUFA group than in the placebo group in women, with no differences (P >0.05) between groups in men. In both sexes, the effect of exercise training on maximal isokinetic torque at 30, 90, and 240° s−1, 4-m walk time, chair-rise time, muscle anatomic cross-sectional area, and muscle fat did not differ (P >0.05) between groups. There was a greater (P <0.05) increase in muscle quality in women after exercise training in the long-chain n–3 PUFA group than in the placebo group, with no such differences in men (P >0.05). Long-chain n–3 PUFAs resulted in a greater decrease (P <0.05) than the placebo in plasma triglyceride concentrations in both sexes, with no differences (P >0.05) in glucose, insulin, or inflammatory markers.  Conclusion: Long-chain n–3 PUFA supplementation augments increases in muscle function and quality in older women but not in older men after resistance exercise training. This trial was registered at clinicaltrials.gov as NCT02843009.
DOI Link: http://dx.doi.org/10.3945/ajcn.116.140780
Rights: This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).

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