Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24350
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dc.contributor.authorCollins, Ianen_UK
dc.contributor.authorBickerstaffe, Adrianen_UK
dc.contributor.authorRanaweera, Thilinaen_UK
dc.contributor.authorMaddumarachchi, Sanjayaen_UK
dc.contributor.authorKeogh, Louiseen_UK
dc.contributor.authorEmery, Jonen_UK
dc.contributor.authorMann, G Bruceen_UK
dc.contributor.authorButow, Phyllisen_UK
dc.contributor.authorWeideman, Prueen_UK
dc.contributor.authorSteel, Emmaen_UK
dc.contributor.authorTrainer, Alisonen_UK
dc.contributor.authorBressel, Mathiasen_UK
dc.contributor.authorHopper, John Len_UK
dc.contributor.authorCuzick, Johnen_UK
dc.contributor.authorAntoniou, Antonis Cen_UK
dc.contributor.authorPhillips, Kelly-Anneen_UK
dc.date.accessioned2018-01-20T05:29:05Z-
dc.date.available2018-01-20T05:29:05Z-
dc.date.issued2016-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24350-
dc.description.abstractWe aimed to develop a user-centered, web-based, decision support tool for breast cancer risk assessment and personalized risk management. Using a novel model choice algorithm, iPrevent® selects one of two validated breast cancer risk estimation models (IBIS or BOADICEA), based on risk factor data entered by the user. Resulting risk estimates are presented in simple language and graphic formats for easy comprehension. iPrevent® then presents risk-adapted, evidence-based, guideline-endorsed management options. Development was an iterative process with regular feedback from multidisciplinary experts and consumers. To verify iPrevent®, risk factor data for 127 cases derived from the Australian Breast Cancer Family Study were entered into iPrevent®, IBIS (v7.02), and BOADICEA (v3.0). Consistency of the model chosen by iPrevent® (i.e., IBIS or BOADICEA) with the programmed iPrevent® model choice algorithm was assessed. Estimated breast cancer risks from iPrevent® were compared with those attained directly from the chosen risk assessment model (IBIS or BOADICEA). Risk management interventions displayed by iPrevent® were assessed for appropriateness. Risk estimation model choice was 100% consistent with the programmed iPrevent®logic. Discrepant 10-year and residual lifetime risk estimates of >1% were found for 1 and 4 cases, respectively, none was clinically significant (maximal variation 1.4%). Risk management interventions suggested by iPrevent® were 100% appropriate. iPrevent® successfully integrates the IBIS and BOADICEA risk assessment models into a decision support tool that provides evidence-based, risk-adapted risk management advice. This may help to facilitate precision breast cancer prevention discussions between women and their healthcare providers.en_UK
dc.language.isoenen_UK
dc.publisherSpringeren_UK
dc.relationCollins I, Bickerstaffe A, Ranaweera T, Maddumarachchi S, Keogh L, Emery J, Mann GB, Butow P, Weideman P, Steel E, Trainer A, Bressel M, Hopper JL, Cuzick J, Antoniou AC & Phillips K (2016) iPrevent®: a tailored, web-based, decision support tool for breast cancer risk assessment and management. Breast Cancer Research and Treatment, 156 (1), pp. 171-182. https://doi.org/10.1007/s10549-016-3726-yen_UK
dc.rights© The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectBreast canceren_UK
dc.subjectRisken_UK
dc.subjectDecision supporten_UK
dc.subjectBRCA1en_UK
dc.subjectChemopreventionen_UK
dc.titleiPrevent®: a tailored, web-based, decision support tool for breast cancer risk assessment and managementen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1007/s10549-016-3726-yen_UK
dc.identifier.pmid26909793en_UK
dc.citation.jtitleBreast Cancer Research and Treatmenten_UK
dc.citation.issn1573-7217en_UK
dc.citation.issn0167-6806en_UK
dc.citation.volume156en_UK
dc.citation.issue1en_UK
dc.citation.spage171en_UK
dc.citation.epage182en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailemma.steel@stir.ac.uken_UK
dc.citation.date24/02/2016en_UK
dc.contributor.affiliationPeter MacCallum Cancer Centreen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationRoyal Women's Hospital (Victoria Australia)en_UK
dc.contributor.affiliationUniversity of Sydneyen_UK
dc.contributor.affiliationPeter MacCallum Cancer Centreen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationPeter MacCallum Cancer Centreen_UK
dc.contributor.affiliationPeter MacCallum Cancer Centreen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.contributor.affiliationQueen Mary, University of Londonen_UK
dc.contributor.affiliationPeter MacCallum Cancer Centreen_UK
dc.contributor.affiliationUniversity of Melbourneen_UK
dc.identifier.isiWOS:000372258800018en_UK
dc.identifier.scopusid2-s2.0-84961154694en_UK
dc.identifier.wtid547651en_UK
dc.contributor.orcid0000-0001-7466-4326en_UK
dc.date.accepted2016-02-16en_UK
dcterms.dateAccepted2016-02-16en_UK
dc.date.filedepositdate2016-10-04en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorCollins, Ian|en_UK
local.rioxx.authorBickerstaffe, Adrian|en_UK
local.rioxx.authorRanaweera, Thilina|en_UK
local.rioxx.authorMaddumarachchi, Sanjaya|en_UK
local.rioxx.authorKeogh, Louise|en_UK
local.rioxx.authorEmery, Jon|en_UK
local.rioxx.authorMann, G Bruce|en_UK
local.rioxx.authorButow, Phyllis|en_UK
local.rioxx.authorWeideman, Prue|en_UK
local.rioxx.authorSteel, Emma|0000-0001-7466-4326en_UK
local.rioxx.authorTrainer, Alison|en_UK
local.rioxx.authorBressel, Mathias|en_UK
local.rioxx.authorHopper, John L|en_UK
local.rioxx.authorCuzick, John|en_UK
local.rioxx.authorAntoniou, Antonis C|en_UK
local.rioxx.authorPhillips, Kelly-Anne|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2016-10-04en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2016-10-04|en_UK
local.rioxx.filenameCollins-etal-BCRT-2016.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0167-6806en_UK
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