Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24109
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dc.contributor.authorSchwartze, Volker Uen_UK
dc.contributor.authorWinter, Saschaen_UK
dc.contributor.authorShelest, Ekaterinaen_UK
dc.contributor.authorMarcet-Houben, Marinaen_UK
dc.contributor.authorHorn, Fabianen_UK
dc.contributor.authorWehner, Stefanieen_UK
dc.contributor.authorLinde, Jorgen_UK
dc.contributor.authorValiante, Vitoen_UK
dc.contributor.authorSammeth, Michaelen_UK
dc.contributor.authorRiege, Konstantinen_UK
dc.contributor.authorNowrousian, Minouen_UK
dc.contributor.authorKaerger, Kerstinen_UK
dc.contributor.authorJacobsen, Ilse Den_UK
dc.contributor.authorMarz, Manjaen_UK
dc.contributor.authorBrakhage, Axel Aen_UK
dc.date.accessioned2017-06-10T22:31:37Z-
dc.date.available2017-06-10T22:31:37Z-
dc.date.issued2014-08-14en_UK
dc.identifier.othere1004496en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24109-
dc.description.abstractLichtheimia species are the second most important cause of mucormycosis in Europe. To provide broader insights into the molecular basis of the pathogenicity-associated traits of the basal Mucorales, we report the full genome sequence of L. corymbifera and compared it to the genome of Rhizopus oryzae, the most common cause of mucormycosis worldwide. The genome assembly encompasses 33.6 MB and 12,379 protein-coding genes. This study reveals four major differences of the L. corymbifera genome to R. oryzae: (i) the presence of an highly elevated number of gene duplications which are unlike R. oryzae not due to whole genome duplication (WGD), (ii) despite the relatively high incidence of introns, alternative splicing (AS) is not frequently observed for the generation of paralogs and in response to stress, (iii) the content of repetitive elements is strikingly low (<5%), (iv) L. corymbifera is typically haploid. Novel virulence factors were identified which may be involved in the regulation of the adaptation to iron-limitation, e.g. LCor01340.1 encoding a putative siderophore transporter and LCor00410.1 involved in the siderophore metabolism. Genes encoding the transcription factors LCor08192.1 and LCor01236.1, which are similar to GATA type regulators and to calcineurin regulated CRZ1, respectively, indicating an involvement of the calcineurin pathway in the adaption to iron limitation. Genes encoding MADS-box transcription factors are elevated up to 11 copies compared to the 1–4 copies usually found in other fungi. More findings are: (i) lower content of tRNAs, but unique codons inL. corymbifera, (ii) Over 25% of the proteins are apparently specific for L. corymbifera. (iii) L. corymbifera contains only 2/3 of the proteases (known to be essential virulence factors) in comparision to R. oryzae. On the other hand, the number of secreted proteases, however, is roughly twice as high as in R. oryzae.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationSchwartze VU, Winter S, Shelest E, Marcet-Houben M, Horn F, Wehner S, Linde J, Valiante V, Sammeth M, Riege K, Nowrousian M, Kaerger K, Jacobsen ID, Marz M & Brakhage AA (2014) Gene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina). PLoS Genetics, 10 (8), Art. No.: e1004496. https://doi.org/10.1371/journal.pgen.1004496en_UK
dc.rights© 2014 Schwartze et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleGene expansion shapes genome architecture in the human pathogen Lichtheimia corymbifera: an evolutionary genomics analysis in the ancient terrestrial mucorales (Mucoromycotina)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pgen.1004496en_UK
dc.identifier.pmid25121733en_UK
dc.citation.jtitlePLoS Geneticsen_UK
dc.citation.issn1553-7404en_UK
dc.citation.issn1553-7390en_UK
dc.citation.volume10en_UK
dc.citation.issue8en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailstefanie.wehner@stir.ac.uken_UK
dc.citation.date14/08/2014en_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.contributor.affiliationLeibniz Institute for Natural Product Research and Infection Biologyen_UK
dc.contributor.affiliationUniversitat Pompeu Fabraen_UK
dc.contributor.affiliationLeibniz Institute for Natural Product Research and Infection Biologyen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationLeibniz Institute for Natural Product Research and Infection Biologyen_UK
dc.contributor.affiliationLeibniz Institute for Natural Product Research and Infection Biologyen_UK
dc.contributor.affiliationCentre Nacional d'Anàlisi Genòmica (CNAG)en_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.contributor.affiliationRuhr-University of Bochum, Germanyen_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.contributor.affiliationPhilipps University of Marburgen_UK
dc.contributor.affiliationFriedrich Schiller University of Jenaen_UK
dc.identifier.isiWOS:000341577800008en_UK
dc.identifier.scopusid2-s2.0-84929144085en_UK
dc.identifier.wtid563424en_UK
dc.contributor.orcid0000-0002-3632-2584en_UK
dc.date.accepted2014-05-24en_UK
dcterms.dateAccepted2014-05-24en_UK
dc.date.filedepositdate2016-08-26en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSchwartze, Volker U|en_UK
local.rioxx.authorWinter, Sascha|en_UK
local.rioxx.authorShelest, Ekaterina|en_UK
local.rioxx.authorMarcet-Houben, Marina|en_UK
local.rioxx.authorHorn, Fabian|en_UK
local.rioxx.authorWehner, Stefanie|0000-0002-3632-2584en_UK
local.rioxx.authorLinde, Jorg|en_UK
local.rioxx.authorValiante, Vito|en_UK
local.rioxx.authorSammeth, Michael|en_UK
local.rioxx.authorRiege, Konstantin|en_UK
local.rioxx.authorNowrousian, Minou|en_UK
local.rioxx.authorKaerger, Kerstin|en_UK
local.rioxx.authorJacobsen, Ilse D|en_UK
local.rioxx.authorMarz, Manja|en_UK
local.rioxx.authorBrakhage, Axel A|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2016-08-26en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2016-08-26|en_UK
local.rioxx.filenamejournal.pgen.1004496.PDFen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1553-7390en_UK
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